Tabis 5 mg (Tablet)

Unit Price: ৳ 10.03 (3 x 10: ৳ 300.90)
Strip Price: ৳ 100.30

Medicine Details

Category Details
Generic Bisoprolol hemifumarate
Company Navana pharmaceuticals ltd
Also available as
Tabis 25 mg tablet

Title

  • Tabis 5 mg Tablet

Categories

  • Medicine
  • Pharmaceutical

Indications

  • Hypertension
  • Angina
  • Moderate to severe heart failure

Pharmacology

  • Selective ß1 blocker
  • Reduces heart rate
  • Reduces cardiac output
  • Decreases arterial hypertension
  • Minimal impact on lipid metabolism
  • High therapeutic reliability
  • Absorbed from gastrointestinal tract
  • Extensively distributed
  • Metabolized via oxidative pathways
  • Renally eliminated
  • Primarily metabolized via CYPSA4
  • Balanced between renal elimination and hepatic metabolism
  • Elimination half-life of 10-12 hours

Dosage & Administration

  • Adult dosage: 5 mg once daily, may be increased to 10 mg and then to 20 mg
  • Children: Safety and effectiveness not established
  • Patients with Renal or Hepatic Impairment: Initial daily dose should be 5 mg
  • Geriatrics: Dose adjustment may be necessary

Interactions

  • Not to be combined with other β-blocking agents
  • Monitor closely when coadministered with catecholamine-depleting drugs
  • Use with care when concurrent use of centrally active antihypertensive agents, antiarrhythmic agents, or calcium channel blockers

Contraindications

  • Cardiogenic shock
  • Overt heart failure
  • Second or third degree A-V block
  • Right ventricular failure secondary to pulmonary hypertension
  • Sinus bradycardia

Side Effects

  • Fatigue
  • Dizziness
  • Headache
  • Disturbances of the gut
  • Cold or numb extremities
  • Muscle weakness or cramps
  • Breathing difficulties
  • Bronchospasm in patients with asthma or COPD

Pregnancy & Lactation

  • Bisoprolol fumarate should be used during pregnancy only if potential benefit justifies potential risk to fetus
  • Potential excretion in human milk; mothers should stop nursing if use is considered essential

Precautions & Warnings

  • Use caution in adjusting dose in patients with renal or hepatic impairment
  • Patients with severe anaphylactic reaction may be more reactive to repeated challenge
  • Unresponsive to usual doses of epinephrine

Therapeutic Class

  • Beta blockers
  • Beta-adrenoceptor blocking drugs

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C<sub>18</sub>H<sub>31</sub>NO<sub>4</sub>

Common Questions

  • Used to lower blood pressure
  • Used to prevent chest pain
  • Can be taken with or without food
  • List of possible side effects
  • Precautions for patients with specific health conditions
  • Recommended dosage after food
  • Storage instructions and quick tips for usage

Other Attributes

  • Most selective &szlig;1 blocker
  • Provides extremely low inter and intra-individual variability of plasma concentration profiles
  • Single daily dose
  • Absolute bioavailability of 88%
  • Initial response to medication may require 2 weeks
  • Low accumulation in patients undergoing dialysis
  • Not teratogenic in rats and rabbits at certain doses
  • Limited studies in pregnant women

Warnings

  • Caution in use with impaired renal or hepatic function
  • Increased reactivity in patients with severe anaphylactic reaction
  • Adverse effects in patients with specific health conditions

Usability

  • Helps to lower blood pressure and reduce chest pain

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