Nubis 5 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Bisoprolol hemifumarate
Company Nuvista pharma ltd
Also available as
Nubis 25 mg tablet

Title

Nubis 5 mg Tablet

Categories

  • Medicine
  • Pharmaceutical

Description

Nubis 5 mg Tablet is a beta-blocker medication used to treat hypertension, angina, and heart failure. It works by blocking the effects of adrenaline, lowering blood pressure, reducing the workload on the heart, and preventing chest pain.

Indications

  • Hypertension
  • Angina
  • Moderate to severe heart failure

Pharmacology

  • High selectivity for ß1 receptor
  • Reduction of arterial hypertension
  • Low inter and intra-individual variability of plasma concentration profiles
  • High therapeutic reliability
  • Almost complete absorption from the gastrointestinal tract
  • Small first-pass effect
  • High bioavailability (88%)
  • Extensive distribution
  • Oxidative metabolism
  • Polar metabolites renally eliminated
  • Primarily metabolized via CYPSA4 (95%)
  • Renal and hepatic elimination
  • Elimination half-life of 10-12 hours

Dosage & administration

  • Adult dosage: 5 mg once daily, may be increased to 10 mg or 20 mg
  • Dose titration interval: 2 weeks
  • Children dosage: Safety and effectiveness not established
  • Patients with Renal or Hepatic Impairment: Initial daily dose should be 5 mg

Interactions

  • Should not be combined with other β-blocking agents
  • Closely monitor patients receiving catecholamine-depleting drugs
  • Caution when coadministered with centrally active antihypertensive agents
  • Careful use when myocardial depressants or calcium channel blockers are used concurrently

Contraindications

Cardiogenic shock, overt heart failure, A-V block, right ventricular failure, sinus bradycardia

Side effects

  • Fatigue
  • Dizziness
  • Headache
  • Disturbances of the gut (nausea, vomiting, diarrhea, constipation, abdominal pain)
  • Cold or numb extremities
  • Muscle weakness or cramps
  • Breathing difficulties (bronchospasm)

Pregnancy & lactation

  • Pregnancy: Use only if potential benefit justifies potential risk to the fetus
  • Lactation: Consider essential use over nursing

Precautions & warnings

  • Use caution in adjusting dose for patients with renal or hepatic impairment
  • Patients with history of severe anaphylactic reaction may be more reactive to allergens

Therapeutic class

Anti-adrenergic agent (Beta blockers)

Storage conditions

Keep in a dry place away from light and heat. Keep out of the reach of children

Chemical structure

  • Molecular Formula: C18H31NO4
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-135-bisoprolol-hemifumarate-chemical-structure-rpXCAgy2GIOFKWUs5Peu.svg

Common questions

  • What is Nubis 5 mg Tablet?: It is a beta-blocker medication used to lower blood pressure, reduce workload on the heart, and prevent chest pain
  • What is Nubis 5 mg Tablet used for?: High blood pressure, Chest pain (angina), and Heart failure
  • How should I take Nubis 5 mg Tablet?: By mouth, with or without food, once daily
  • What are the side effects of Nubis 5 mg Tablet?: Dizziness, Fatigue, Headache, Slow heart rate, Difficulty breathing, Cold hands and feet
  • Is Nubis 5 mg Tablet safe to take?: Generally safe, but consult doctor if having health conditions
  • Should I use Nubis 5 mg Tablet empty stomach, before or after food?: After food
  • What are the instructions for the storage and disposal of Nubis 5 mg Tablet?: Keep in a cool dry place in original packaging, out of reach of children and pets
  • Quick Tips:
    • May cause dizziness. Get up slowly from sitting or lying position
    • Can hide symptoms of low blood sugar if diabetic. Monitor blood sugar levels regularly
    • Do not stop suddenly to avoid sudden rise in blood pressure

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