Preloc 50 mg (Tablet)
Unit Price: ৳ 2.00 (5 x 10: ৳ 100.00)
Strip Price: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metoprolol tartrate |
| Company | Opsonin pharma ltd |
Indications
- Hypertension management
- Angina pectoris
- Cardiac arrhythmias
- Hyperthyroidism treatment
- Pain relief in myocardial infarction
- Reduction of mortality in myocardial infarction patients
Pharmacology
- Selective beta1-blocker
- Reduction of heart rate
- Reduction of blood pressure
- Interference with Insulin release
- Interference with carbohydrate metabolism
Dosage & Administration
- Total daily dosage range: 100-400 mg
- Single or twice-daily dosing
- Initial dose: 100 mg per day
- Titration at weekly intervals
- Extended-release dosage options
- IV injection dosage for different indications
Interaction
- Additive effect with catecholamine-depleting drugs
- Inhibition of CYP2D6 by certain drugs
- Concomitant use with digitalis glycosides
- Exacerbation of rebound hypertension by clonidine withdrawal
Contraindications
- AV block
- Uncontrolled heart failure
- Severe bradycardia
- Sick-sinus syndrome
- Cardiogenic shock
- Severe peripheral arterial disease
- Known hypersensitivity to Metoprolol or other B-blockers
Side Effects
- Tiredness
- Dizziness
- Depression
- Diarrhea
- Itching or rash
- Shortness of breath
- Slow heart rate
- Mental confusion
- Headache
- Somnolence
- Nightmares
- Insomnia
- Dyspnea
- Nausea
- Dry mouth
- Gastric pain
- Constipation
- Flatulence
- Digestive tract disorders
- Heartburn
- Pruritus
- Musculoskeletal pain
- Blurred vision
- Decreased libido
- Tinnitus
- Intensification of AV block
Pregnancy & Lactation
- Pregnancy Category C
- Excretion in breast milk
- Caution during lactation
Precautions & Warnings
- Caution in bronchospastic diseases
- Controversy over withdrawing therapy prior to major surgery
- Masking of tachycardia occurring with hypoglycemia
- Aggravation of arterial insufficiency in peripheral vascular disease
- Caution with concomitant use of calcium channel blockers
Use in Special Populations
- Caution in hepatic impaired patients
- Adverse event profile in pediatric patients
- Safety and effectiveness in patients <6 years of age
- Efficacy and adverse events in geriatric patients
Overdose Effects
- Severe hypotension
- Sinus bradycardia
- Atrioventricular block
- Heart failure
- Cardiogenic shock
- Bronchospasm
- Impairment of consciousness
- Coma
- Nausea
- Vomiting
- Cyanosis
- Hypoglycemia
- Hyperkalemia
- Treatment options
Storage Conditions
- Cool and dry storage
- Protection from light