Selomet 25 mg (Tablet)
Unit Price: ৳ 1.50 (3 x 10: ৳ 45.00)
Strip Price: ৳ 15.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metoprolol tartrate |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Hypertension management
- Angina pectoris management
- Cardiac arrhythmias management
- Adjunct treatment of hyperthyroidism
- Reduction of infarct size in acute myocardial infarction
- Pain relief
- Reduction of mortality in acute myocardial infarction
Pharmacology
- Selective beta1-blocker
- Reduction of agonistic effect on the heart of catecholamines
- Reduction of heart rate, cardiac output, cardiac contractility, and blood pressure
- Interference with insulin release and carbohydrate metabolism
- Interference with the cardiovascular response to hypoglycemia
Dosage & Administration
- Total daily dosage of 100-400 mg for hypertension
- Initial dosage of 50-100 mg for angina pectoris
- Dosage up to 300 mg per day for cardiac arrhythmias
- Dosage regimen for hyperthyroidism
- Therapy commencement for myocardial infarction
- Usual initial dosage of 25-100 mg for extended-release tablet
- IV Injection dosage for arrhythmias, surgery, and myocardial infarction
Interaction
- Additive effect with catecholamine-depleting drugs
- Increase in Selomet concentration with CYP2D6 inhibiting drugs
- Increased risk of bradycardia with concomitant use of digitalis glycosides and beta-blockers
- Exacerbation of rebound hypertension with beta-blockers withdrawal of clonidine
Contraindications
- AV block
- Uncontrolled heart failure
- Severe bradycardia
- Sick-sinus syndrome
- Cardiogenic shock
- Severe peripheral arterial disease
- Known hypersensitivity to Metoprolol or other B-blockers
Side Effects
- Tiredness
- Dizziness
- Depression
- Diarrhea
- Itching or rash
- Shortness of breath
- Slow heart rate
- Mental confusion
- Headache
- Somnolence
- Nightmares
- Insomnia
- Dyspnea
- Nausea
- Dry mouth
- Gastric pain
- Constipation
- Flatulence
- Digestive tract disorders
- Heartburn
- Pruritus
- Musculoskeletal pain
- Blurred vision
- Decreased libido
- Tinnitus
- Intensification of AV block
Pregnancy & Lactation
- Pregnancy Category C
- Excretion in breast milk
- Caution in nursing women
Precautions & Warnings
- Use with caution in bronchospastic diseases
- Controversy regarding withdrawal prior to major surgery
- Masking of tachycardia with hypoglycemia
- Aggravation of symptoms of arterial insufficiency in patients with peripheral vascular disease
- Caution in patients treated concomitantly with calcium channel blockers
Use in Special Populations
- Caution in patients with impaired hepatic function
- Safety and effectiveness in pediatric patients
- No notable differences in efficacy or adverse events between older and younger patients
Overdose Effects
- Severe hypotension
- Sinus bradycardia
- Atrioventricular block
- Heart failure
- Cardiogenic shock
- Cardiac arrest
- Bronchospasm
- Impairment of consciousness
- Coma
- Nausea
- Vomiting
- Cyanosis
- Hypoglycemia
- Hyperkalemia
- Treatment measures
Storage Conditions
- Cool and dry place
- Protected from light