Selomet-SR 50 mg (Tablet (Extended Release))
Unit Price: ৳ 4.00 (3 x 10: ৳ 120.00)
Strip Price: ৳ 40.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metoprolol tartrate |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Management of hypertension
- Management of angina pectoris
- Treatment of cardiac arrhythmias
- Adjunct in the treatment of hyperthyroidism
- Reduction of infarct size in acute myocardial infarction
- Decrease in the need for opiate analgesics
- Reduction of mortality in patients with acute myocardial infarction
Pharmacology
- Selective beta1-blocker
- Reduction of heart rate
- Reduction of cardiac output
- Reduction of cardiac contractility
- Reduction of blood pressure
- Interference with Insulin release
- Interference with carbohydrate metabolism
Dosage & Administration
- Available as film-coated tablets
- Available as extended-release tablets
- Available for intravenous injection
- Individualized dosage for hypertension and angina pectoris
- Specific dosages for different cardiac arrhythmias
- Special dosage for hyperthyroidism
- Initiation of therapy for myocardial infarction 15 minutes after the last injection
Interaction
- Additive effect with catecholamine-depleting drugs
- Increased concentration with CYP2D6 inhibitors
- Increased risk of bradycardia with digitalis glycosides
- Exacerbation of rebound hypertension with clonidine withdrawal
Contraindications
- AV block
- Uncontrolled heart failure
- Severe bradycardia
- Sick-sinus syndrome
- Cardiogenic shock
- Severe peripheral arterial disease
- Known hypersensitivity to Metoprolol or other B-blockers
Side Effects
- Tiredness
- Dizziness
- Depression
- Diarrhea
- Itching or rash
- Shortness of breath
- Slow heart rate
- Mental confusion
- Headache
- Somnolence
- Nightmares
- Insomnia
- Dyspnea
- Nausea
- Dry mouth
- Gastric pain
- Constipation
- Flatulence
- Digestive tract disorders
- Heartburn
- Pruritus
- Musculoskeletal pain
- Blurred vision
- Decreased libido
- Tinnitus
- Intensification of AV block
Pregnancy & Lactation
- Pregnancy Category C
- Excretion in breast milk in very small quantities
- Caution for administration to nursing women
Precautions & Warnings
- Caution in patients with bronchospastic disease
- Controversy regarding withdrawal prior to major surgery
- Masking of tachycardia occurring with hypoglycemia
- Possible aggravation of symptoms in patients with peripheral vascular disease
- Caution in patients treated with calcium channel blockers concomitantly
Use in Special Populations
- Caution in patients with impaired hepatic function
- Safety and effectiveness not established in patients <6 years of age
Overdose Effects
- Severe hypotension
- Sinus bradycardia
- Atrioventricular block
- Cardiac arrest
- Bronchospasm
- Impairment of consciousness
- Coma
- Nausea
- Vomiting
- Cyanosis
- Hypoglycemia
- Hyperkalemia
- Manifestations appearing 20 minutes to 2 hours after ingestion
- Treatment involving close monitoring of cardiovascular, respiratory, and renal function
- Treatment may include sympathomimetic agents, inotropic agents, and temporary pacing for AV block
- Glucagon administration to reverse excessive B-blockade
- Intravenous B2-stimulants for relieving bronchospasm
Storage Conditions
- Store in a cool and dry place
- Protected from light