Infanil 500 mg (Tablet)

Unit Price: ৳ 45.00 (8's pack: ৳ 360.00)

Medicine Details

Category	Details
Generic	Cefuroxime axetil
Company	Novelta bestway pharma ltd
Also available as	Infanil 250 mg tablet Infanil 125 mg suspension

Indications

Treatment of infections caused by sensitive bacteria
Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis
Acute bacterial maxillary sinusitis
Lower respiratory tract infections including pneumoniae
Skin and skin-structure infections
Urinary tract infections
Bone and Joint Infections
Gonorrhoea
Early Lyme Disease (erythema migrans)

Pharmacology

Cefuroxime is a well-characterized and effective antibacterial agent with broad-spectrum bactericidal activity against a wide range of common pathogens, including β-lactamase producing strains.

Dosage

Tablet or Suspension:
- Adolescents and adults (13 years and older):
  - Pharyngitis/tonsillitis: 250 mg b.i.d. for 5-10 days
  - Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days
  - Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days
  - Secondary bacterial infections of acute bronchitis: 250-500 mg b.i.d. for 5-10 days
  - Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for 10 days
  - Uncomplicated urinary tract infections: 250 mg b.i.d. for 7-10 days
  - Uncomplicated Gonorrhoea: 1000 mg Single dose
  - Community acquired pneumonia: 250-500 mg b.i.d. for 5-10 days
  - MDR Typhoid Fever: 500 mg b.i.d. for 10-14 days
  - Early Lyme disease: 500 mg b.i.d. for 20 days
- Paediatric Patients (3 months to 12 years):
  - Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d for 5-10 days
  - Acute otitis media: 30 mg/kg/day b.i.d for 10 days
  - Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d for 10 days
  - Impetigo: 30 mg/kg/day b.i.d for 10 days
Parenteral:
- Adult: 750 mg three times daily by IM or IV injection
- Children (above 3 months of age): 30 - 100 mg/kg/day given in 3 or 4 equally divided doses
- Neonate: 30 - 100 mg/kg/day given in 2 or 3 equally divided doses
- Surgical prophylaxis: 1.5 gm by IV injection at induction of anaesthesia; up to 3 further doses of 750 mg may be given by IV/IM injection every 8 hours for high risk procedures
- Pneumonia: 1.5 gm IV injection twice daily for 2-3 days, followed by 500 mg twice daily (oral) for 7-10 days
- Acute exacerbations of chronic bronchitis: 750 mg twice daily (IM or IV injection) for 2-3 days, followed by 500 mg twice daily (oral) for 5-10 days
- Gonorrhoea: 1.5 gm as a single dose
Meningitis:
- Adult: 3 gm IV injection three times daily
- Children (above 3 months of age): 200-240 mg/kg/day by IV injection in 3 or 4 divided doses reduced to 100 mg/kg/day after 3 days or on clinical improvement
- Neonate: 100 mg/kg/day by IV injection at initial dose, reduced to 50 mg/kg/day when clinically indicated
Bone and joint infections:
- Adult: 1.5 gm IV injection four times daily
- Children (above 3 months of age): 150 mg/kg/day (not to exceed the maximum adult dose) in equally divided doses every 8 hours

Administration

The use of freshly reconstituted solution is recommended. It maintains potency for at least 24 hours at room temperature or 48 hours at 5°C.

Interaction

No potentially hazardous interactions have been reported.

Contraindications

Cefuroxime is contraindicated in patients with known allergy to Cephalosporins.

Side Effects

Adverse effects have occurred infrequently and have been generally mild and transient in nature. Effects reported include rashes and gastrointestinal disturbances. Prolonged use may result in the overgrowth of non-susceptible organisms, e.g. Candida.

Pregnancy & Lactation

US FDA pregnancy category of Cefuroxime is B. Caution should be exercised when Cefuroxime is administered to a nursing woman.

Precautions & Warnings

Infanil should be given with care to patients receiving concurrent treatment with potent diuretics & who has history of colitis. Cephalosporin antibiotics may be given safely to patients who are hypersensitive to penicillin although cross reactions have been reported.

Therapeutic Class

Second generation Cephalosporins

Reconstitution

For 750 mg intramuscular injection: Add 3 ml water for injection to vial and then shake gently for dispersion.
For 750 mg intravenous injection: Add 8 ml water for injection to vial and then shake gently for dispersion. The solution should be slowly injected directly into a vein over a 3 to 5 minutes period.
For 1.5 g intravenous injection: Add 16 ml Water for injection to vial and then shake gently for dispersion. The solution should be slowly injected directly into a vein over a 3 to 5 minutes period.

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.