Sharpkil 250 mg (Tablet)
Unit Price: ৳ 25.00 (2 x 6: ৳ 300.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cefuroxime axetil |
| Company | One pharma ltd |
| Also available as |
Title
- Cefuroxime Tablet
- Cefuroxime Suspension
Categories
- Antibiotic
- Medication
Indications
- Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
- Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase producing strains) or Streptococcus pyogenes
- Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae
- Lower respiratory tract infections including pneumoniae, caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pyogenes, E. coli
- Acute bacterial exacerbation of chronic bronchitis and Secondary bacterial infections of Acute bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae (beta-lactamase negative strains) or Haemophilus parainfluenzae (beta-lactamase negative strains)
- Skin and skin-structure infections caused by Staphylococcus aureus (including beta-lactamase producing strains) or Streptococcus pyogenes
- Urinary tract infections caused by E.coli or Klebsiella pneumoniae
- Bone and Joint Infections caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains)
- Gonorrhoea caused by penicillinase-producing and non-penicillinase producing strains of Neisseria gonorrhoeae
- Early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi
Pharmacology
- Broad-spectrum bactericidal activity
- Active against β-lactamase producing strains
- Good stability to bacterial β-lactamase
Dosage
- 250 mg b.i.d. for 5-10 days for Adolescents and adults (13 years and older)
- 20 mg/kg/day b.i.d for 5-10 days for Paediatric Patients (3 months to 12 years)
- 750 mg three times daily by IM or IV injection for Adult
- 30 - 100 mg/kg/day given in 3 or 4 equally divided doses for Children (above 3 months of age)
- 1.5 gm by IV injection at induction of anaesthesia for Surgical prophylaxis
Administration
- Use of freshly reconstituted solution recommended
- Maintains potency for at least 24 hours at room temperature or 48 hours at 5° C
Interaction
- No potentially hazardous interactions reported
Contraindications
- Known allergy to Cephalosporins
Side Effects
- Adverse effects occurred infrequently
- Mild and transient in nature
- Rashes and gastrointestinal disturbances reported
- Prolonged use may result in overgrowth of non susceptible organisms e.g. Candida
Pregnancy & Lactation
- US FDA pregnancy category of Cefuroxime is B
- Excreted in human milk
- Caution should be exercised when administered to a nursing woman
Precautions & Warnings
- Give with care to patients receiving concurrent treatment with potent diuretics & who has history of colitis
- Cephalosporin antibiotics may be given safely to patients who are hypersensitive to penicillin
Therapeutic Class
- Second generation Cephalosporins
Reconstitution
- For 750 mg intramuscular injection: Add 3 ml water for injection to vial and then shake gently for dispersion
- For 750 mg intravenous injection: Add 8 ml water for injection to vial and then shake gently for dispersion
- For 1.5 g intravenous injection: Add 16 ml Water for injection to vial and then shake gently for dispersion
Storage Conditions
- Store in a cool, dry place (below 30° C)
- Away from light & moisture
- Keep out of the reach of children