Roximax 250 mg (Tablet)

Unit Price: ৳ 25.07 (2 x 10: ৳ 501.40)

Strip Price: ৳ 250.70

Medicine Details

Category	Details
Generic	Cefuroxime axetil
Company	Veritas pharmaceuticals ltd
Also available as	Roximax 500 mg tablet

Indications

Treatment of infections caused by sensitive bacteria
Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
Acute Bacterial Otitis Media caused by Streptococcus pneumoniae
Acute bacterial maxillary sinusitis caused by Haemophilus influenzae
Lower respiratory tract infections including pneumoniae
Skin and skin-structure infections
Urinary tract infections
Bone and Joint Infections
Gonorrhoea
Early Lyme Disease (erythema migrans)

Pharmacology

Cefuroxime is a well-characterized and effective antibacterial agent, with broad-spectrum bactericidal activity against a wide range of common pathogens, including β-lactamase producing strains.

Dosage

Tablet or Suspension:
- Adolescents and adults (13 years and older):
  - Pharyngitis/tonsillitis: 250 mg b.i.d. for 5-10 days
  - Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days
  - Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days
  - Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for 10 days
  - Uncomplicated urinary tract infections: 250 mg b.i.d. for 7-10 days
  - Uncomplicated Gonorrhoea: 1000 mg Single dose
  - Community acquired pneumonia: 250-500 mg b.i.d. for 5-10 days
- Paediatric Patients (3 months to 12 years):
  - Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d for 5-10 days
  - Acute otitis media: 30 mg/kg/day b.i.d for 10 days
Parenteral:
- Adult: 750 mg three times daily by IM or IV injection
- Children (above 3 months of age): 30 - 100 mg/kg/day given in 3 or 4 equally divided doses

Administration

The use of freshly reconstituted solution is recommended. However, it maintains potency for at least 24 hours at room temperature or 48 hours at 5°C

Interaction

No potentially hazardous interactions have been reported.

Contraindications

Cefuroxime is contraindicated in patients with known allergy to Cephalosporins.

Side Effects

Adverse effects to Roximax have occurred infrequently and have been generally mild and transient in nature. Effects reported include rashes and gastrointestinal disturbances. Prolonged use may result in the overgrowth of non susceptible organisms e.g. Candida.

Pregnancy & Lactation

US FDA pregnancy category of Cefuroxime is B. Caution should be exercised when administered to a nursing woman.

Precautions & Warnings

Roximax should be given with care to patients receiving concurrent treatment with potent diuretics & who has history of colitis. Cephalosporin antibiotics may be given safely to patients who are hypersensitive to penicillin although cross reactions have been reported.

Therapeutic Class

Second generation Cephalosporins

Reconstitution

For 750 mg intramuscular injection: Add 3 ml water for injection to vial and then shake gently for dispersion. For 750 mg intravenous injection: Add 8 ml water for injection to vial and then shake gently for dispersion. For 1.5 g intravenous injection: Add 16 ml Water for injection to vial and then shake gently for dispersion. The solution should be slowly injected directly into a vein over a 3 to 5 minute period.

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.