Gutset 5 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 40.12

Medicine Details

Category Details
Generic Domperidone maleate
Company Ad din pharmaceuticals ltd
Also available as
Gutset 10 mg tablet Gutset 5 mg pediatric drop

Title

Gutset 5 mg/5 ml Suspension

Categories

  • Medicine
  • Gastrointestinal Health

Description

Dopamine antagonist medication used to treat dyspeptic symptoms, acute nausea and vomiting, Parkinson's disease, and speeding barium transit in radiological studies.

DosageAndAdministration

  • To be taken 15-30 minutes before meals
  • Usual adult dose: 10-20 mg (1-2 tablets or 10-20 ml suspension) every 6-8 hours daily
  • Maximum dose: 80 mg daily
  • Children's dose: 2-4 ml suspension/10 kg body weight every 6-8 hours daily

Pharmacology

Blocks dopamine receptors in the Chemoreceptor-Trigger Zone and stomach, restores normal motility and tone of the upper gastrointestinal tract, facilitates gastric emptying, enhances antral and duodenal peristalsis, and regulates contraction of the pylorus.

Interaction

  • Antagonized by anticholinergic drugs
  • Simultaneous use with antacids and antisecretory drugs lowers oral bioavailability
  • Metabolic pathway involves CYP3A4

Contraindications

  • Hypersensitivity to the drug
  • Neonates
  • Gastrointestinal hemorrhage, mechanical obstruction or perforation
  • Prolactin releasing pituitary tumor

SideEffects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena
  • Possible increase in plasma prolactin level
  • Rare allergic reactions like rash and urticaria

PregnancyAndLactation

  • Use in first trimester justified by therapeutic benefit
  • Not recommended during nursing unless benefits outweigh risks
  • Does not affect mental alertness

PrecautionsAndWarnings

  • Increased risk of extra-pyramidal reactions in young children
  • Caution in patients with hepatic impairment

UseInSpecialPopulations

  • Caution in infants due to immature blood-brain barrier
  • Caution in patients with hepatic impairment
  • Dosage frequency should be reduced in severe renal insufficiency

OverdoseEffects

  • Symptoms may include drowsiness and extrapyramidal reactions
  • Activated charcoal administration recommended

TherapeuticClass

Motility Stimulants, Dopamine Antagonists, Prokinetic Drugs

StorageConditions

Store below 30°C, protected from light and moisture

ChemicalStructure

  • MolecularFormula: C22H24ClN5O2
  • ChemicalStructureImageLink: https://medex.com.bd/storage/res/g-res-380-domperidone-maleate-chemical-structure-4Q6P0Z8laWrV7xnOkSMm.svg

CommonQuestions

    • Question: What is Gutset 5 mg/5 ml Suspension used for?
    • Answer: Used to treat nausea and vomiting
    • Question: Quick Tips
    • Answer:
      • Helps relieve nausea, vomiting, and indigestion
      • May cause dizziness and sleepiness
      • Avoid alcohol consumption
      • Dry mouth may occur as a side effect
      • Inform your doctor if you experience certain symptoms

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