Alfradin 500 mg (Capsule)

Unit Price: ৳ 12.50

Medicine Details

Category Details
Generic Cephradine
Company Allied pharmaceuticals ltd
Also available as
Alfradin ds 250 mg suspension

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections
  • Susceptible microorganisms (Gram-positive and Gram-negative)
  • Staphylococci
  • Streptococci
  • Escherichia coli
  • Klebsiella spp
  • Proteus mirabilis
  • Haemophilus influenza
  • Shigella spp
  • Salmonella spp
  • Neisseria spp

Pharmacology

  • Semisynthetic broad-spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibition of cell wall cross-linking process
  • Lysis of bacteria due to external osmotic pressure

Dosage & Administration

  • Oral administration for adults and children
  • Dosage based on infection site and severity
  • Maximum daily dosage
  • Dosage for elderly and patients with impaired renal or hepatic function
  • Injectable administration for adults and children

Interaction

  • Concomitant use of nephrotoxic drugs
  • Enhanced risk of renal toxicity by diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastrointestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Rare reactions (glossitis, heartburn, dizziness, nausea, etc.)
  • Blood and lymphatic system disorders
  • Immune system disorders
  • Psychiatric disorders
  • Nervous system disorders
  • Hepatobiliary disorders
  • Renal and urinary disorders
  • Investigations

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excretion in breast milk
  • Caution in lactating mothers
  • Potential for causing dizziness

Precautions & Warnings

  • Development of superinfection with prolonged use
  • Care in patients hypersensitive to penicillins
  • Potential positive result in Coombs’ testing
  • Potential false positive urine glucose result
  • Dosage adjustment in renal impairment
  • Lactose content caution for certain patients

Use in Special Populations

  • Recommended doses for patients not on haemodialysis
  • Recommended doses for patients on chronic, intermittent haemodialysis
  • Higher doses for chronic or severe infections
  • Monitoring required for chronic urinary tract infections
  • Caution in paediatric dosages

Overdose Effects

  • Non-specific symptoms (nausea, vomiting, diarrhea)
  • Supportive treatment
  • Necessity of gastric lavage

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Fresh preparation of Alfradin Suspension
  • Shelf life of reconstituted Suspension
  • Shelf life of Alfradin Injection solutions
  • Storage temperature impact on solution potency
  • Variability in reconstituted solution color
  • Proper disposal as per prescription

Related Brands