Alfradin 500 mg (Capsule)
Unit Price: ৳ 12.50
Medicine Details
| Category | Details |
|---|---|
| Generic | Cephradine |
| Company | Allied pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
- Upper respiratory tract infections
- Lower respiratory tract infections
- Urinary tract infections
- Skin and soft tissue infections
- Susceptible microorganisms (Gram-positive and Gram-negative)
- Staphylococci
- Streptococci
- Escherichia coli
- Klebsiella spp
- Proteus mirabilis
- Haemophilus influenza
- Shigella spp
- Salmonella spp
- Neisseria spp
Pharmacology
- Semisynthetic broad-spectrum bactericidal antibiotic
- Active against both gram-positive and gram-negative microorganisms
- Inhibition of cell wall cross-linking process
- Lysis of bacteria due to external osmotic pressure
Dosage & Administration
- Oral administration for adults and children
- Dosage based on infection site and severity
- Maximum daily dosage
- Dosage for elderly and patients with impaired renal or hepatic function
- Injectable administration for adults and children
Interaction
- Concomitant use of nephrotoxic drugs
- Enhanced risk of renal toxicity by diuretics and probenecid
Contraindications
- Hypersensitivity to cephalosporins
Side Effects
- Gastrointestinal disturbances
- Hypersensitivity phenomena
- Skin reactions
- Rare reactions (glossitis, heartburn, dizziness, nausea, etc.)
- Blood and lymphatic system disorders
- Immune system disorders
- Psychiatric disorders
- Nervous system disorders
- Hepatobiliary disorders
- Renal and urinary disorders
- Investigations
Pregnancy & Lactation
- Safety in pregnancy not established
- Excretion in breast milk
- Caution in lactating mothers
- Potential for causing dizziness
Precautions & Warnings
- Development of superinfection with prolonged use
- Care in patients hypersensitive to penicillins
- Potential positive result in Coombs’ testing
- Potential false positive urine glucose result
- Dosage adjustment in renal impairment
- Lactose content caution for certain patients
Use in Special Populations
- Recommended doses for patients not on haemodialysis
- Recommended doses for patients on chronic, intermittent haemodialysis
- Higher doses for chronic or severe infections
- Monitoring required for chronic urinary tract infections
- Caution in paediatric dosages
Overdose Effects
- Non-specific symptoms (nausea, vomiting, diarrhea)
- Supportive treatment
- Necessity of gastric lavage
Therapeutic Class
- First generation Cephalosporins
Storage Conditions
- Fresh preparation of Alfradin Suspension
- Shelf life of reconstituted Suspension
- Shelf life of Alfradin Injection solutions
- Storage temperature impact on solution potency
- Variability in reconstituted solution color
- Proper disposal as per prescription