Alfradin DS 250 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 120.00

Medicine Details

Category Details
Generic Cephradine
Company Allied pharmaceuticals ltd
Also available as
Alfradin 500 mg capsule

Title

Alfradin DS

Categories

  • Medicine
  • Antibiotic

Description

Alfradin DS is a semisynthetic broad-spectrum bactericidal antibiotic, active against infections caused by both gram-positive and gram-negative microorganisms.

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections: sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis, otitis media
  • Lower respiratory tract infections: bronchitis, lobar pneumonia, bronchopneumonia
  • Urinary tract infections: cystitis, urethritis, pyelonephritis
  • Skin and soft tissue infections: abscess, cellulitis, furunculosis, impetigo

Pharmacology

Cephradine inhibits cross-linking process of peptidoglycan in the cell wall of bacteria, leading to lysis of bacteria due to external osmotic pressure

DosageAndAdministration

  • OralAdministration:
    • Adults:
      • Urinary tract infections: 500mg four times daily or 1g twice daily
      • Respiratory tract infections: 250-500mg four times daily or 500mg-1g twice daily
      • Skin and soft tissue infections: 250-500mg four times daily or 500mg-1g twice daily
    • Children:
      • Total daily dose: 25-50mg/kg given in two or four equally divided doses
      • Otitis media: Total daily dose: 75-100mg/kg given in divided doses
    • Elderly: Normal adult dose is appropriate. Patients with impaired renal or hepatic function should be monitored during treatment
  • InjectableAdministration:
    • Adult: Usual dose: 2-4 gm daily in four equally divided doses, up to 8 gm daily

Interactions

Concomitant use of nephrotoxic drugs may increase risk of kidney damage, diuretics and probenecid enhance renal toxicity

Contraindications

Hypersensitivity to cephalosporins

SideEffects

  • Gastrointestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Glossitis
  • Heartburn
  • Dizziness
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Vaginitis
  • Candida overgrowth

PregnancyAndLactation

Safety in pregnancy not established, excreted in breast milk, caution in lactating mothers

PrecautionsAndWarnings

  • Prolonged use may result in superinfection
  • Care with penicillin hypersensitivity
  • May cause false positive urine glucose result
  • Dosage adjustment necessary in renal impairment
  • Contains lactose, caution in patients with galactose intolerance

UseInSpecialPopulations

  • RenalImpairment:
    • CrCl>20 ml/min: 500mg every 6 hours
    • CrCl: 5-20 ml/min: 250mg every 6 hours
    • CrCl: <5 ml/min: 250mg every 50-70 hours
    • Chronic, intermittent haemodialysis: 250mg at the start of haemodialysis

OverdoseEffects

Nausea, vomiting, diarrhoea, gastric upsets

TherapeuticClass

First generation Cephalosporins

StorageConditions

Suspension should be used within 7 days if kept at room temperature or within 14 days if kept in a refrigerator, Injection solutions should be used within 2 hours when kept at room temperature

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