Amfrad 500 mg (Capsule)

Unit Price: ৳ 12.54 (24's pack: ৳ 300.96)

Medicine Details

Category Details
Generic Cephradine
Company Amulet pharmaceuticals ltd
Also available as
Amfrad 250 mg capsule Amfrad 125 mg suspension

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections (sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis, otitis media)
  • Lower respiratory tract infections (bronchitis, lobar pneumonia, bronchopneumonia)
  • Urinary tract infections (cystitis, urethritis, pyelonephritis)
  • Skin and soft tissue infections (abscess, cellulitis, furunculosis, impetigo)

Pharmacology

  • Broad-spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in bacterial cell walls
  • Mainly acts on the cell wall of bacteria

Dosage & Administration

  • Dosage for adults and children for oral administration
  • Dosage for injectable administration
  • Dosage adjustment in renal impairment
  • Maximum daily dosage: 4 gm
  • Caution in elderly patients

Interaction

  • Risk of kidney damage with concomitant use of nephrotoxic drugs
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastrointestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Hypersensitivity reactions
  • Blood disorders
  • Immune system disorders
  • Psychiatric disorders
  • Nervous system disorders
  • Hepatobiliary disorders
  • Renal and urinary disorders
  • Elevation of blood urea nitrogen

Pregnancy & Lactation

  • Excreted in breast milk
  • Caution in lactating mothers
  • Safety in pregnancy not established

Precautions & Warnings

  • Risk of superinfection with prolonged use
  • Caution in patients hypersensitive to penicillins
  • Potential positive result in Coombs’ testing
  • Potential false positive urine glucose result

Use in Special Populations

  • Recommended doses for patients with renal impairment
  • Additional information for all patients

Overdose Effects

  • Non-specific symptoms include nausea, vomiting, diarrhea, gastric upsets
  • Supportive treatment
  • Gastric lavage may be necessary

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Reconstituted Suspension should be used within 7-14 days
  • Injection solutions retain potency for 2-12 hours
  • Reconstituted solutions may vary in color
  • Keep all medicines out of the reach of children

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