Amfrad 250 mg (Capsule)

Unit Price: ৳ 6.25 (30's pack: ৳ 187.50)

Medicine Details

Category Details
Generic Cephradine
Company Amulet pharmaceuticals ltd
Also available as
Amfrad 500 mg capsule Amfrad 125 mg suspension

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against gram-positive and gram-negative microorganisms
  • Inhibition of cross-linking process in bacteria cell wall
  • Bactericidal action due to cell wall lysis

Dosage & Administration

  • Oral and injectable administration
  • Specific doses for adults and children
  • Max daily dosage
  • Dosage adjustment in elderly and renal impaired patients

Interaction

  • Nephrotoxic drug interaction risk
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastrointestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Blood and lymphatic system disorders
  • Immune system disorders
  • Psychiatric disorders
  • Nervous system disorders
  • Hepatobiliary disorders
  • Renal and urinary disorders
  • Elevation of serum parameters

Pregnancy & Lactation

  • No established safety in pregnancy
  • Excretion in breast milk
  • Caution in lactating mothers

Precautions & Warnings

  • Development of superinfection
  • Cross-sensitivity with penicillins
  • Cephalosporin antibiotics may cause a positive result in Coombs’ testing
  • Potential for false positive urine glucose result
  • Lactose content precautions
  • Dosage adjustment in renal impairment

Use in Special Populations

  • Renal impairment dosing recommendations
  • Higher doses for chronic or severe infections
  • Monitoring in chronic urinary tract infections
  • Transference from intramuscular/intravenous to oral treatment

Overdose Effects

  • Non-specific symptoms
  • Supportive treatment
  • Possible need for gastric lavage

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Shelf life of reconstituted suspension
  • Potency retention of injection solutions
  • Dispensing on prescription only

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