Alphapress 1 mg (Tablet)

Indications

• Essential hypertension treatment
• Secondary hypertension treatment
• Treatment of left ventricular failure
• Treatment of Raynaud's phenomenon and Raynaud's disease
• Adjunct in the symptomatic treatment of urinary obstruction caused by benign prostatic hyperplasia

Pharmacology

• Decrease in total peripheral vascular resistance
• Selective inhibition of postsynaptic alpha-1-adrenoreceptors
• Lowering of blood pressure in supine and standing positions
• Reduction in left ventricular filling pressure
• Reduction in cardiac impedance
• Augmentation of cardiac output
• Improvement in urinary pressure profile in men with benign prostatic hyperplasia
• No adverse changes in the serum lipid profile

Dosage & Administration

• Initiation of therapy with a low starting dose
• Adjustment of dosage based on individual toleration
• Gradual dosage increase until desired effect or maximum dosage is reached
• Different dosing regimens based on patient's current antihypertensive therapy, renal function, and condition being treated
• Recommended starting dosage and usual daily maintenance dosage for each indication

Interaction

• Clinical experience showing no adverse drug interactions with cardiac glycosides, hypoglycemic agents, tranquilizers and sedatives, antiarrhythmic agents, analgesic, antipyretic and anti-inflammatory agents

Contraindications

• Known sensitivity to quinazolines

Side Effects

• Common reactions including dizziness, headache, drowsiness, lack of energy, weakness, palpitations, nausea, vomiting
• Additional reactions such as diarrhea, constipation, abdominal discomfort, liver function abnormalities, pancreatitis, edema, orthostatic hypotension, dyspnea, faintness, tachycardia, nervousness, vertigo, hallucinations, depression, rash, pruritus, alopecia, urinary frequency, impotence

Pregnancy & Lactation

• No teratogenic effects seen in animal testing
• Use during pregnancy only if the potential benefit justifies the potential risk to the mother and fetus
• Excretion in small amounts in human milk

Precautions & Warnings

• Postural hypotension precautions for patients with hypertension
• Careful adjustment of diuretic dosage for patients with left ventricular failure
• Close monitoring of blood pressure for patients with Raynaud's Phenomenon/Disease and benign prostatic hyperplasia
• Not recommended for children under 12 years

Use in Special Populations

• Not recommended for children under 12 years
• Not recommended for left ventricular failure due to mechanical obstruction or recent myocardial infarction

Overdose Effects

• Support of the cardiovascular system in case of hypotension
• Monitoring and support of renal function
• Non-dialyzable because it is protein bound

Therapeutic Class

• Alpha adrenoceptor blocking drugs

Storage Conditions

• Store away from light and moisture
• Store below 30°C
• Keep away from reach of children

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