Alphapress 2 mg (Tablet)

Indications

• Treatment of Hypertension
• Treatment of Left Ventricular Failure
• Treatment of Raynaud's Phenomenon and Disease
• Symptomatic treatment of Benign Prostatic Hyperplasia

Pharmacology

• Decrease in total peripheral vascular resistance
• Selective inhibition of postsynaptic alpha-1-adrenoreceptors
• Effect on blood pressure in hypertensive patients
• Effect on left ventricular filling pressure and cardiac output
• Reduction in severity of signs and symptoms of Raynaud's disease
• Improvement in urinary pressure profile in men with BPH
• No adverse changes in serum lipid profile

Dosage & Administration

• Initial therapy with a low starting dose
• Dosage adjustment based on patient's response
• Use as initial and sole agent or in combination with other antihypertensive drugs
• Various dosage regimens for hypertension
• Recommended starting dosage for Left Ventricular Failure, Raynaud's, and BPH
• Prazosin XR Extended-Release Tablets dosage initiation and titration

Interaction

• No adverse drug interaction observed in clinical experience
• Details of no adverse interaction with specific drug categories

Contraindications

• Contraindicated in patients with known sensitivity to quinazolines

Side Effects

• Common reactions including dizziness, headache, drowsiness, palpitations, nausea
• Other reactions such as vomiting, diarrhea, edema, orthostatic hypotension, rash, impotence
• Occasional reports of worsening of pre-existing narcolepsy
• Specific side effects in patients with left ventricular failure and Raynaud's Phenomenon/Disease

Pregnancy & Lactation

• No teratogenic effects seen in animal testing
• Use during pregnancy and lactation should be cautious and justified by potential benefit

Precautions & Warnings

• Caution for postural hypotension in hypertension
• Importance of observance of recommended starting dose in Left Ventricular Failure
• Monitoring of blood pressure and medication interactions in Raynaud's and BPH

Use in Special Populations

• Not recommended for children under 12 years
• Not recommended in specific conditions of left ventricular failure
• No adequate data for efficacy in recent myocardial infarction

Overdose Effects

• Management of accidental ingestion overdose effects
• Support of the cardiovascular system in case of hypotension
• Monitoring and support of renal function

Therapeutic Class

• Alpha adrenoceptor blocking drugs

Storage Conditions

• Store below 30°C, away from light and moisture
• Keep out of reach of children

Related Brands

• Alphapress 1 mg (Tablet) - renata-limited