Libradin 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 80.30

Medicine Details

Category Details
Generic Cephradine
Company Libra pharmaceuticls ltd
Also available as
Libradin 500 mg capsule

Title

  • Libradin

Categories

  • Medicine
  • Pharmaceutical

Description

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Dosage for oral and injectable administration
  • Interactions with nephrotoxic drugs, diuretics, and probenecid
  • Contraindications for patients with known or suspected hypersensitivity to cephalosporins
  • Potential side effects such as gastrointestinal disturbances, hypersensitivity reactions, and skin reactions
  • Use in pregnancy and lactation
  • Precautions for prolonged use, cross-sensitivity with penicillins, and false positive urine glucose result
  • Dosing recommendations for renal impairment and special populations
  • Symptoms and treatment of overdose effects
  • Therapeutic class as first generation Cephalosporins
  • Storage conditions for suspension and injection solutions

Indications

  • Upper respiratory tract infections including sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis, and otitis media
  • Lower respiratory tract infections including bronchitis (acute and chronic), lobar pneumonia, and bronchopneumonia
  • Urinary tract infections including cystitis, urethritis, and pyelonephritis
  • Skin and soft tissue infections including abscess, cellulitis, furunculosis, and impetigo

Pharmacology

  • Cephradine is a semisynthetic broad spectrum bactericidal antibiotic
  • Active against infections caused by both gram-positive and gram-negative microorganisms
  • Inhibition of cross-linking process in the cell wall of bacteria leading to lysis

Dosage & Administration

  • Oral administration for adults and children
  • Injectable administration for adults and children
  • Dosage adjustments for elderly and patients with impaired renal or hepatic function

Interaction

  • Concomitant use of nephrotoxic drugs increase the risk of kidney damage

Contraindications

  • Should not be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

  • Gastrointestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Blood disorders
  • Immune system disorders
  • Psychiatric disorders
  • Nervous system disorders
  • Hepatobiliary disorders
  • Renal and urinary disorders
  • Elevation of blood urea nitrogen and serum creatinine

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excretion in breast milk
  • Caution in lactating mothers

Precautions & Warnings

  • Prolonged use may result in the development of superinfection
  • Administered with care to patients hypersensitive to penicillins
  • Cephalosporin antibiotics may cause a positive Coombs test
  • May cause a false positive urine glucose result
  • Dosage adjustment necessary in renal impairment
  • Contains lactose

Use in Special Populations

  • Recommended doses for patients not on haemodialysis and on chronic, intermittent haemodialysis
  • Higher doses may be required for chronic or severe infections

Overdose Effects

  • Non-specific symptoms include nausea, vomiting, and diarrhea
  • Treatment is mainly supportive

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Suspension should be freshly prepared
  • Reconstituted Suspension should be used within 7-14 days depending on storage temperature
  • Injection solutions should be used within 2 hours when kept at room temperature, and 12 hours when stored at 5°C
  • Do not use later than the date of expiry
  • To be dispensed only on the prescription of a registered physician

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