Sporin 125 mg/1.25 ml (Pediatric Drops)

Indications

• Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
• Upper respiratory tract infections like sinusitis, pharyngitis, otitis media
• Lower respiratory tract infections like bronchitis, pneumonia
• Urinary tract infections like cystitis, pyelonephritis
• Skin and soft tissue infections like cellulitis, abscess
• Susceptible microorganisms: Staphylococci, Streptococci, Escherichia coli, Klebsiella spp
• Effective against penicillin-resistant strains and penicillinase-producing species

Pharmacology

• Broad spectrum bactericidal antibiotic
• Active against gram-positive and gram-negative microorganisms
• Main site of action is the cell wall of bacteria, inhibits cross-linking process

Dosage & Administration

• Adult oral dosage: 250mg-1g depending on the site and severity of infection
• Child oral dosage: 25-50mg/kg in divided doses
• Injectable dosage: 2-4g daily in four equally divided doses
• Maximum daily dosage: 4g
• Dosage adjustment necessary in renal impairment

Interaction

• Concomitant use with nephrotoxic drugs may increase risk of kidney damage
• Diuretics and probenecid enhance possibility of renal toxicity

Contraindications

• Should not be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

• Limited to gastrointestinal disturbances and hypersensitivity phenomena
• Possible skin reactions, glossitis, heartburn, dizziness, nausea

Pregnancy & Lactation

• Safety in pregnancy not established
• Excreted in breast milk, caution in lactating mothers

Precautions & Warnings

• Prolonged use may result in development of superinfection
• Administer with care to patients hypersensitive to penicillins
• May cause false positive urine glucose result with certain tests

Use in Special Populations

• Recommended doses for renal impairment and haemodialysis patients

Overdose Effects

• Non-specific symptoms like nausea, vomiting, diarrhoea

Therapeutic Class

• First generation Cephalosporins

Storage Conditions

• Suspension should be freshly prepared and used within specified timeframe
• Injection solutions retain potency for specific durations
• Keep all medicines out of children's reach

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