Cilnipin 5 mg (Tablet)

Indications

• Management of hypertension for end-organ protection
• Useful in elderly patients
• Useful in patients with diabetes and albuminuria
• Useful in patients with chronic kidney disease

Pharmacology

• Dihydropyridine calcium-channel blocker
• Binds to L-type voltage dependent calcium channel
• Inhibits Ca2+ influx across the cell membranes
• Causes vasodilation
• Inhibits Ca2+ influx via N-type voltage dependent calcium channels
• Suppresses reflex increase in heart rate after blood pressure reduction

Dosage & Administration

• Adults: 5-10 mg once daily after breakfast
• Maximum dose: 20 mg once daily
• Pediatric use: Safety not established
• Elderly use: Initiate therapy with lowest possible dose (5 mg)

Interaction

• Interacts with other anti-hypertensive drugs
• Interacts with antipsychotics causing hypotension
• Interacts with quinidine, carbamazepine, phenytoin, rifampicin, cimetidine, erythromycin

Contraindications

• Contraindicated in patients with known sensitivity to Cilnidipine or any excipients
• Contraindicated in patients with cardiogenic shock, recent MI or acute unstable angina
• Contraindicated in patients with severe aortic stenosis

Side Effects

• Dizziness
• Flushing
• Headache
• Hypotension
• Peripheral edema
• Palpitations
• GI disturbances
• Increased micturition frequency
• Lethargy
• Eye pain
• Depression

Pregnancy & Lactation

• Not to be administered in pregnant or possibly pregnant women
• To be avoided in nursing mothers
• Patient should discontinue lactation if administration is indispensable

Precautions & Warnings

• Administer with care in patients with serious hepatic dysfunction
• Administer with care in patients with history of serious adverse reactions to calcium antagonists
• Gradually decrease dosage during discontinuation under close observation

Therapeutic Class

• Calcium-channel blockers

Storage Conditions

• Store below 30°C
• Protected from light and moisture
• Keep away from reach of children

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