Mydipin 5 mg (Tablet)
Unit Price: ৳ 7.00 (3 x 14: ৳ 294.00)
Strip Price: ৳ 98.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cilnidipine |
| Company | Drug international ltd |
| Also available as |
Indications
- Indicated for the management of hypertension for end-organ protection
- Useful in elderly patients and those with diabetes and albuminuria
- Increasingly used in patients with chronic kidney disease
Pharmacology
- Dihydropyridine calcium-channel blocker
- Binds to the dihydropyridine binding sites of the L-type voltage dependent calcium channel
- Inhibits Ca2+ influx across the cell membranes of vascular smooth muscle cells
- Inhibits Ca2+ influx via N-type voltage dependent calcium channels in sympathetic nerve cell membrane
- Causes vasodilation
- Considered to suppress the reflex increase in heart rate after blood pressure reduction
Dosage & Administration
- Adults: 5-10 mg once daily after breakfast
- Maximum dose: 20 mg once daily
- Pediatric use: Safety not established
- Elderly use: Initiated with the lowest possible dose (5 mg)
Interaction
- Interacts with other anti-hypertensive medications
- Interacts with antipsychotics that cause hypotension
- Interacts with quinidine, carbamazepine, phenytoin, rifampicin, cimetidine, erythromycin
Contraindications
- Contraindicated in patients with known sensitivity to Cilnidipine or any of the excipients
- Contraindicated in patients with cardiogenic shock, recent MI, acute unstable angina, and severe aortic stenosis
Side Effects
- Dizziness
- Flushing
- Headache
- Hypotension
- Peripheral edema
- Palpitations
- GI disturbances
- Increased micturition frequency
- Lethargy
- Eye pain
- Depression
Pregnancy & Lactation
- Not to be administered in pregnant or potentially pregnant women
- To be avoided in nursing mothers
- If indispensable, patient should be instructed to discontinue lactation
Precautions & Warnings
- Administered with care in patients with serious hepatic dysfunction
- Administered with care in patients with a history of serious adverse reactions to calcium antagonists
- Dosage should be gradually decreased during discontinuation under close observation
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Store below 30°C
- Protected from light and moisture
- Keep away from children's reach