Mydipin 10 mg (Tablet)

Indications

• Management of hypertension for end-organ protection
• Useful in elderly patients and those with diabetes and albuminuria
• Increasingly used in patients with chronic kidney disease

Pharmacology

• Dihydropyridine calcium-channel blocker
• Binds to dihydropyridine binding sites of L-type voltage dependent calcium channel
• Inhibits Ca2+ influx across cell membranes of vascular smooth muscle cells
• Causes vasodilation
• Inhibits Ca2+ influx via N-type voltage dependent calcium channels in sympathetic nerve cell membrane
• Inhibits release of norepinephrine from sympathetic nerve terminals

Dosage & Administration

• Adults: 5-10 mg once daily after breakfast
• Maximum dose: 20 mg once daily
• Pediatric use not established
• Elderly use: Initiate therapy with lowest possible dose

Interaction

• Other anti-hypertensive medications
• Antipsychotics causing hypotension
• Quinidine
• Carbamazepine
• Phenytoin
• Rifampicin
• Cimetidine
• Erythromycin

Contraindications

• Known sensitivity to Cilnidipine or excipients
• Cardiogenic shock
• Recent MI or acute unstable angina
• Severe aortic stenosis

Side Effects

• Dizziness
• Flushing
• Headache
• Hypotension
• Peripheral edema
• Palpitations
• GI disturbances
• Increased micturition frequency
• Lethargy
• Eye pain
• Depression

Pregnancy & Lactation

• Not for pregnant or potentially pregnant women
• Avoid administration to nursing mothers
• Discontinue lactation if administration is indispensable

Precautions & Warnings

• Use with care in patients with serious hepatic dysfunction
• History of serious adverse reactions to calcium antagonists
• Gradually decrease dosage during discontinuation under close observation

Therapeutic Class

• Calcium-channel blockers

Storage Conditions

• Store below 30°C
• Protected from light and moisture
• Keep away from reach of children

Related Brands

• Cilnipin 5 mg (Tablet) - aristopharma-ltd
• Cilnipin 10 mg (Tablet) - aristopharma-ltd
• Mydipin 5 mg (Tablet) - drug-international-ltd