LNC 10 mg (Tablet)
Unit Price: ৳ 9.00 (1 x 30: ৳ 270.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Cilnidipine |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Management of hypertension for end-organ protection
- Useful in elderly patients
- Useful in patients with diabetes and albuminuria
- Useful in patients with chronic kidney disease
Pharmacology
- Dihydropyridine calcium-channel blocker
- Binds to the L-type voltage dependent calcium channel
- Inhibits Ca2+ influx across the cell membranes of vascular smooth muscle cells
- Induces vasodilation
- Inhibits Ca2+ influx via N-type voltage dependent calcium channels
- Inhibits release of norepinephrine from sympathetic nerve terminals
- Suppresses reflex increase in heart rate after blood pressure reduction
Dosage & Administration
- Adults: 5-10 mg once daily after breakfast
- Maximum dose: 20 mg once daily
- Pediatric use: Safety not established
- Elderly use: Initiate therapy with lowest possible dose (5 mg)
Interaction
- Interacts with other anti-hypertensive drugs
- Interacts with antipsychotics that cause hypotension
- Interacts with quinidine, carbamazepine, phenytoin, rifampicin, cimetidine, and erythromycin
Contraindications
- Known sensitivity to Cilnidipine or any of the excipients
- Cardiogenic shock
- Recent MI or acute unstable angina
- Severe aortic stenosis
Side Effects
- Dizziness
- Flushing
- Headache
- Hypotension
- Peripheral edema
- Palpitations
- GI disturbances
- Increased micturition frequency
- Lethargy
- Eye pain
- Depression
Pregnancy & Lactation
- Contraindicated in pregnant women
- Contraindicated in women with possibilities of being pregnant
- Avoid administration to nursing mothers
- Discontinue lactation if administration is indispensable
Precautions & Warnings
- Administer with care in patients with serious hepatic dysfunction
- Administer with care in patients with a history of serious adverse reactions to calcium antagonists
- Gradually decrease dosage during discontinuation under close observation
Therapeutic Class
Calcium-channel blockers
Storage Conditions
- Store below 30°C
- Protected from light and moisture
- Keep away from reach of children