Duocard 5 mg (Tablet)
Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cilnidipine |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Management of hypertension for end-organ protection
- Useful in elderly patients with diabetes and albuminuria
- Increasingly used in patients with chronic kidney disease
Pharmacology
- Dihydropyridine calcium-channel blocker
- Binds to dihydropyridine binding sites of L-type voltage dependent calcium channel
- Inhibits Ca2+ influx across cell membranes of vascular smooth muscle cells
- Causes vasodilation and relaxation of vascular smooth muscle
- Inhibits Ca2+ influx via N-type voltage dependent calcium channels in sympathetic nerve cell membrane
- Suppresses reflex increase in heart rate after blood pressure reduction
Dosage & Administration
- Adults: 5-10 mg once daily after breakfast
- Maximum dose: 20 mg once daily
- Pediatric use safety not established
- Use caution in elderly patients
Interaction
- May interact with other anti-hypertensive and antipsychotic drugs causing hypotension
- Also interacts with quinidine, carbamazepine, phenytoin, rifampicin, cimetidine, and erythromycin
Contraindications
- Known sensitivity to Cilnidipine or any of the excipients
- Cardiogenic shock, recent MI, acute unstable angina, and severe aortic stenosis
Side Effects
- Dizziness
- Flushing
- Headache
- Hypotension
- Peripheral edema
- Palpitations
- GI disturbances
- Increased micturition frequency
- Lethargy
- Eye pain
- Depression
Pregnancy & Lactation
- Should not be administered in pregnant or possibly pregnant women
- Avoid administration to nursing mothers
- Discontinue lactation if administration is indispensable
Precautions & Warnings
- Administer with caution in patients with serious hepatic dysfunction
- Consider history of serious adverse reactions to calcium antagonists
- Gradually decrease dosage during discontinuation under close observation
Therapeutic Class
Calcium-channel blockers
Storage Conditions
- Store below 30°C
- Protect from light and moisture
- Keep away from reach of children