Duocard 10 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cilnidipine |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Management of hypertension for end-organ protection
- Useful in elderly patients
- Useful in patients with diabetes and albuminuria
- Useful in patients with chronic kidney disease
Pharmacology
- Cilnidipine is a dihydropyridine calcium-channel blocker
- Binds to the dihydropy-ridine binding sites of the L-type voltage dependent calcium channel
- Inhibits Ca2+ influx across the cell membranes of vascular smooth muscle cells
- Causes vasodilation
- Inhibits Ca2+ influx via N-type voltage dependent calcium channels in the sympathetic nerve cell membrane
- Inhibition of Ca2+ influx via N-type voltage dependent calcium channel also inhibits release of norepinephrine
- Suppresses the reflex increase in heart rate after blood pressure reduction
Dosage & Administration
- Adults: 5-10 mg once daily after breakfast
- Maximum dose: 20 mg once daily
- Pediatric use: Safety not established
- Elderly use: Initiate therapy with the lowest possible dose (5 mg)
Interaction
- Other anti-hypertensive medications
- Antipsychotics causing hypotension
- Quinidine
- Carbamazepine
- Phenytoin
- Rifampicin
- Cimetidine
- Erythromycin
Contraindications
- Known sensitivity to Cilnidipine or any excipients
- Cardiogenic shock
- Recent MI or acute unstable angina
- Severe aortic stenosis
Side Effects
- Dizziness
- Flushing
- Headache
- Hypotension
- Peripheral edema
- Palpitations
- GI disturbances
- Increased micturition frequency
- Lethargy
- Eye pain
- Depression
Pregnancy & Lactation
- Avoid use in pregnant women
- Avoid use in women with possibilities of being pregnant
- Avoid administration to nursing mothers
- Discontinue lactation if administration is indispensable
Precautions & Warnings
- Administer with care in patients with serious hepatic dysfunction
- Administer with care in patients with a history of serious adverse reactions to calcium antagonists
- Gradually decrease dosage during discontinuation under close observation
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Store below 30°C
- Protected from light and moisture
- Keep away from reach of children