Albendol 400 mg (Chewable Tablet)
Unit Price: ৳ 3.50 (50's pack: ৳ 175.00)
Medicine Details
Category | Details |
---|---|
Generic | Albendazole |
Company | Globex pharmaceuticals ltd |
Also available as |
Indications
- Single and mixed infestations of hookworm, roundworm, threadworm, whipworm, strongyloides, tapeworm, opisthorchi, hydatid
Description
- Benzimidazole anthelmintic
- Active against most nematodes and some cestodes
- Vermicidal, ovicidal, and larvicidal activity
- Inhibitory effect on tubulin polymerization
- Loss of cytoplasmic microtubules
Pharmacology
- Broad spectrum anthelmintic
- Block glucose uptake in susceptible helminths
- Depletion of energy level in helminths
- Immobilization and parasite death
- Extensively metabolized, probably in the liver
- Poorly absorbed from the gastrointestinal tract
- Rapid first-pass metabolism
- Principal metabolite with anthelmintic activity
Dosage & Administration
- 400 mg single dose for various infections
- 400 mg daily for 3 days in strongyloidiasis or taeniasis
- 200 mg single dose for children of 1-2 years
- Not recommended for children under 1 year
- Dosing for hydatid disease and giardiasis
Interaction
- No reported pharmacodynamic or pharmacokinetic interaction
Contraindications
- Not normally used in neonates
- Dose reduction in children weighing less than 10 kg
- Not recommended during pregnancy or lactation
- No need for dose alteration in renal, hepatic, or cardiac failure
Side Effects
- Gastrointestinal disturbances
- Headache
- Dizziness
- Changes in liver enzymes
- Rarely reversible alopecia
- Rash
- Fever
- Blood disorders
- Allergic shock if cyst leakage
- Convulsion and meningism in cerebral disease
Pregnancy & Lactation
- Category C pregnancy risk
- Avoidance in pregnancy and lactation unless benefits outweigh risks
Precautions & Warnings
- Blood counts and liver function tests before and during treatment
- Breastfeeding considerations
- Pregnancy exclusion before treatment
- Constant medical supervision in Echinococcosis treatment
Therapeutic Class
- Anthelmintic
Storage Conditions
- Keep in a dry place
- Away from light and heat
- Keep out of the reach of children