Tofanib XR 11 mg (Tablet (Extended Release))
Unit Price: ৳ 80.00 (1 x 10: ৳ 800.00)
Strip Price: ৳ 800.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tofacitinib |
| Company | Globe pharmaceuticals ltd |
| Also available as |
Indications
- Rheumatoid Arthritis
- Psoriatic Arthritis
- Ulcerative Colitis
Pharmacology
Tofacitinib is a partial and reversible janus kinase (JAK) inihibitor that prevents the body from responding to cytokine signals. By inhibiting JAKs, tofacitinib prevents the phosphorylation and activation of STATs. It works therapeutically by inhibiting the JAK-STAT pathway to decrease the inflammatory response.
Dosage & Administration
- Tofacitinib 5 mg twice daily
- Tofacitinib 11 mg once daily
- Tofacitinib 10 mg twice daily for ulcerative colitis
Interaction
- Potent inhibitors of Cytochrome P450 3A4 (CYP3A4) (e.g., Ketoconazole)
- Moderate inhibition of CYP3A4 and potent inhibition of CYP2C19 (e.g., fluconazole)
- Potent CYP inducers (e.g.Rifampin)
Side Effects
The most commonly reported adverse reactions during the first 3 months were upper respiratory tract infections, headache, diarrhea, and nasopharyngitis.
Pregnancy & Lactation
Pregnancy Category C. Tofacitinib should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Precautions & Warnings
- Serious Infections
- Gastrointestinal Perforations
- Laboratory Monitoring
- Immunizations
- Absolute lymphocyte count <500 cells/mm3, absolute neutrophil count <1000 cells/mm3, hemoglobin <9 gm/dL
Use in Special Populations
- Pediatric Use
- Geriatric Use
- Moderate and severe renal impairment or moderate hepatic impairment
Therapeutic Class
Immunosuppressant
Storage Conditions
Store below 30°C. Protect from light & moisture. Keep all medicines out of the reach of children.