Tofacent 5 mg (Tablet)
Unit Price: ৳ 35.00 (2 x 10: ৳ 700.00)
Strip Price: ৳ 350.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tofacitinib |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Rheumatoid Arthritis
- Psoriatic Arthritis
- Ulcerative Colitis
Pharmacology
- Autoimmune disease
- Dysregulation of pro-inflammatory cytokines
- Janus kinase (JAK) inhibitor
- Inhibition of JAK-STAT pathway
- Decrease in inflammatory response
Dosage & Administration
- Recommended dosage for rheumatoid arthritis
- Recommended dosage for psoriatic arthritis
- Recommended dosage for ulcerative colitis
- Dosage adjustment for renal impairment
- Dosage adjustment for hepatic impairment
Interaction
- Inhibitors of Cytochrome P450 3A4 (CYP3A4)
- Concomitant medications with moderate inhibition of CYP3A4 and potent inhibition of CYP2C19
- CYP inducers leading to reduced clinical response
Side Effects
- Upper respiratory tract infections
- Headache
- Diarrhea
- Nasopharyngitis
Pregnancy & Lactation
- Pregnancy Category C
- Use during pregnancy
- Excretion in human milk
- Decision for nursing mothers
Precautions & Warnings
- Avoid use during active serious infection
- Use with caution in patients at increased risk of gastrointestinal perforations
- Recommended laboratory monitoring
- Avoid use with live vaccines
- Do not initiate if absolute lymphocyte count <500 cells/mm3
- Do not initiate if absolute neutrophil count <1000 cells/mm3
- Do not initiate if hemoglobin <9 gm/dL
Use in Special Populations
- Pediatric Use
- Geriatric Use
- Renal impairment dosage adjustment
- Hepatic impairment dosage adjustment
Therapeutic Class
- Immunosuppressant
Storage Conditions
- Store below 30°C
- Protect from light and moisture
- Keep out of reach of children