Tofatin XR 11 mg (Tablet (Extended Release))
Unit Price: ৳ 80.00 (1 x 10: ৳ 800.00)
Strip Price: ৳ 800.00
Medicine Details
Category | Details |
---|---|
Generic | Tofacitinib |
Company | Ziska pharmaceuticals ltd |
Also available as |
Indications
- Rheumatoid Arthritis: treatment for moderately to severely active rheumatoid arthritis
- Psoriatic Arthritis: treatment for active psoriatic arthritis
- Ulcerative Colitis: treatment for moderately to severely active ulcerative colitis
Pharmacology
- Targeted cytokines: IL7, IL15, IL21, IL6, IFN-alpha, and IFN-beta
- Inhibition of JAK-STAT signaling pathway
- Reduction of tissue inflammation and joint damage
Dosage & Administration
- Tofacitinib 5 mg twice daily for rheumatoid arthritis
- Tofacitinib 11 mg once daily for rheumatoid arthritis
- Tofacitinib 10 mg twice daily for ulcerative colitis
Interaction
- Inhibited by potent CYP3A4 inhibitors
- Contraindicated with potent CYP inducers
- Dose adjustment for concomitant medications
Side Effects
- Common adverse reactions: upper respiratory tract infections, headache, diarrhea, nasopharyngitis
Pregnancy & Lactation
- Pregnancy Category C
- Use during pregnancy only if benefit justifies potential risk
- Unknown excretion in human milk
Precautions & Warnings
- Avoid use during active serious infections
- Use with caution in patients at risk of gastrointestinal perforations
- Recommended laboratory monitoring for potential changes in blood parameters
Use in Special Populations
- Safety and effectiveness not established in pediatric patients
- Higher risk of serious infections in elderly population
- Dose adjustment for renal or hepatic impairment
Therapeutic Class
- Immunosuppressant
Storage Conditions
- Store below 30°C
- Protect from light and moisture
- Keep out of the reach of children
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