Tofatin XR 11 mg (Tablet (Extended Release))

Unit Price: ৳ 80.00 (1 x 10: ৳ 800.00)
Strip Price: ৳ 800.00

Medicine Details

Category Details
Generic Tofacitinib
Company Ziska pharmaceuticals ltd
Also available as
Tofatin 5 mg tablet

Indications

  • Rheumatoid Arthritis: treatment for moderately to severely active rheumatoid arthritis
  • Psoriatic Arthritis: treatment for active psoriatic arthritis
  • Ulcerative Colitis: treatment for moderately to severely active ulcerative colitis

Pharmacology

  • Targeted cytokines: IL7, IL15, IL21, IL6, IFN-alpha, and IFN-beta
  • Inhibition of JAK-STAT signaling pathway
  • Reduction of tissue inflammation and joint damage

Dosage & Administration

  • Tofacitinib 5 mg twice daily for rheumatoid arthritis
  • Tofacitinib 11 mg once daily for rheumatoid arthritis
  • Tofacitinib 10 mg twice daily for ulcerative colitis

Interaction

  • Inhibited by potent CYP3A4 inhibitors
  • Contraindicated with potent CYP inducers
  • Dose adjustment for concomitant medications

Side Effects

  • Common adverse reactions: upper respiratory tract infections, headache, diarrhea, nasopharyngitis

Pregnancy & Lactation

  • Pregnancy Category C
  • Use during pregnancy only if benefit justifies potential risk
  • Unknown excretion in human milk

Precautions & Warnings

  • Avoid use during active serious infections
  • Use with caution in patients at risk of gastrointestinal perforations
  • Recommended laboratory monitoring for potential changes in blood parameters

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients
  • Higher risk of serious infections in elderly population
  • Dose adjustment for renal or hepatic impairment

Therapeutic Class

  • Immunosuppressant

Storage Conditions

  • Store below 30°C
  • Protect from light and moisture
  • Keep out of the reach of children

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