Pulfibro 267 mg (Tablet)
Unit Price: ৳ 45.00 (3 x 10: ৳ 1,350.00)
Strip Price: ৳ 450.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pirfenidone |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of mild to moderate Idiopathic Pulmonary Fibrosis (IPF)
Pharmacology
- Anti-inflammatory properties
- Antioxidant properties
- Anti-fibrotic properties
- Improvement of lung function
- Reduction of acute exacerbations
- Suppression of TGF-β1
- Downregulation of pro-inflammatory cytokines
- Inhibition of inflammatory cells influx
- Inhibition of increased pulmonary vascular permeability
Dosage & Administration
- Orally administered
- Recommended daily dose of nine 267 mg tablets or three 801 mg tablet per day
- Titration regimen for initiating treatment
- Dose adjustments for gastrointestinal events
- Dose adjustments for photosensitivity reaction or rash
- Dose adjustments for hepatic function
- Guidelines for treatment interruption and re-initiation
Interaction
- Interaction with moderate and strong inhibitors of CYP1A2
- Effect of food on adverse reactions
Contraindications
- Hypersensitivity to the active substance or excipients
- Concomitant use of fluvoxamine
- Severe hepatic impairment or end stage liver disease
- Severe renal impairment or end stage renal disease requiring dialysis
Side Effects
- Common side effects
- Rare side effects
Pregnancy & Lactation
- Precautionary avoidance during pregnancy
- Unknown excretion in human milk
- Effects on fertility and reproductive performance in rats
Precautions & Warnings
- Monitoring of liver enzymes
- Precautions for photosensitivity and rash
- Precautions for gastrointestinal disorders
Use in Special Populations
- Safety and effectiveness in children & adolescents
- Monitoring and dosage modification for hepatic impairment
- Monitoring and dosage modification for renal impairment
- Decreased exposure in smokers
Overdose Effects
- Limited clinical experience with overdose
- Adverse reactions from multiple doses
Therapeutic Class
- Immunosuppressant
Storage Conditions
- Cool and dry storage
- Protection from light and moisture
- Keep out of reach of children