Pulfibro 801 mg (Tablet)
Unit Price: ৳ 125.00 (1 x 10: ৳ 1,250.00)
Strip Price: ৳ 1,250.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pirfenidone |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of mild to moderate Idiopathic Pulmonary Fibrosis (IPF)
Pharmacology
- Anti-inflammatory properties
- Antioxidant properties
- Anti-fibrotic properties
- Improvement of lung function
- Reduction of acute exacerbations in patients with IPF
- Suppression of TGF-β1
- Downregulation of pro-inflammatory cytokines
Dosage & Administration
- Route of administration: oral with food
- Recommended daily dose for IPF patients
- Dose titration schedule
- Dose adjustments for gastrointestinal events
- Dose adjustments for photosensitivity reaction or rash
- Dose adjustments for hepatic function
Interaction
- Moderate and strong inhibitors of CYP1A2 increase systemic exposure
- Dosage reduction with specific medicine use
- Reduced incidence of adverse reactions in fed group
Contraindications
- Hypersensitivity to active substance or excipients
- Concomitant use of fluvoxamine
- Severe hepatic impairment or end stage liver disease
- Severe renal impairment or end stage renal disease requiring dialysis
Side Effects
- Common side effects
- Rare side effects
Pregnancy & Lactation
- No data available for pregnant women
- Placental transfer of pirfenidone in animals
- Precautionary avoidance during pregnancy
- Unknown excretion in human milk
- Effects on fertility and reproductive performance in rats
Precautions & Warnings
- Monitoring of liver enzymes
- Photosensitivity and rash precautions
- Gastrointestinal disorder precautions
Use in Special Populations
- Safe and effective use in children & adolescents not known
- Use in hepatic impairment
- Use in renal impairment
- Effect of smoking on exposure
Overdose Effects
- Limited clinical experience with overdose
- Adverse reactions reported with high dose
Therapeutic Class
- Immunosuppressant
Storage Conditions
- Cool and dry storage
- Protection from light and moisture
- Keep out of reach of children