Acepril 5 mg (Tablet)
Unit Price: ৳ 4.05 (4 x 14: ৳ 226.80)
Strip Price: ৳ 56.70
Medicine Details
| Category | Details |
|---|---|
| Generic | Lisinopril |
| Company | Drug international ltd |
| Also available as |
Indications
- Treatment of hypertension in adult patients
- Treatment of hypertension in pediatric patients (6 years of age and older)
- Lowering blood pressure
- Reducing risk of cardiovascular events
- Treatment of heart failure
- Reduction of mortality in acute myocardial infarction
Pharmacology
- Competitively inhibits ACE
- Increases plasma renin activity
- Reduces aldosterone secretion
- Promotes vasodilation
- Blood pressure reduction
Dosage
- Initial dosage of 10 mg/day for hypertension in adults
- Initial dosage of 2.5-5 mg for severe hypertension
- Maintenance dosage of up to 80 mg/day may be given if needed
- Dosage adjustment for diabetic nephropathy
- Adjunct dosage for heart failure
- Dosage for post-myocardial infarction
- Dosage for pediatric hypertension (≥6 years)
Administration
May be taken with or without food
Interaction
- Enhances hypotensive effect with diuretics
- Increases risk of renal function deterioration with NSAIDs
- Increases serum levels and toxicity of lithium
- Increased risk of hyperkalaemia with K-sparing diuretics and K supplements
Contraindications
- History of angioedema related to previous ACE inhibitor treatment
- Concomitant use with aliskiren in patients with diabetes or renal impairment
- Pregnancy
- Children with GFR <30 mL/min/1.73 m²
Side Effects
- Headache
- Fatigue
- Persistent and non-productive cough
- Dizziness
- Nausea
- Vomiting
- Diarrhoea
- Rash
- Hypotension
- Renal dysfunction
- Hyperkalaemia
Pregnancy & Lactation
Category D: Positive evidence of human foetal risk
Precautions & Warnings
- Bilateral renal artery stenosis or a single kidney with unilateral renal artery stenosis
- Patients with collagen vascular disease
- Acute MI at risk of further haemodynamic deterioration
- Angioedema unrelated to ACE inhibitor therapy
- Aortic stenosis and hypertrophic cardiomyopathy
- Increased risk of angioedema in black patients
- Renal impairment
Use in Special Populations
- Dosage adjustments based on creatinine clearance for adults
- Avoid in children if GFR <30 mL/min/1.73 m²
Overdose Effects
- Hypotension
- Tachycardia
- Renal failure
- Electrolyte disturbances
- Anxiety
- Dizziness
Therapeutic Class
Angiotensin-converting enzyme (ACE) inhibitors
Storage Conditions
Store at below 25° C