Actemra 162 mg/0.9 ml (SC Injection)
0.9 ml pre-filled syringe: ৳ 19,923.20
Medicine Details
| Category | Details |
|---|---|
| Generic | Tocilizumab |
| Company | Roche bangladesh ltd |
| Also available as |
Indications
- Rheumatoid Arthritis
- Polyarticular Juvenile Idiopathic Arthritis
- Systemic Juvenile Idiopathic Arthritis
- COVID-19
- Cytokine Release Syndrome
- Giant Cell Arteritis
- Systemic Sclerosis-Associated Interstitial Lung Disease
Pharmacology
- Anti-inflammatory
- IL-6 receptor antagonist
- Immunoglobulin IgG1K subclass
- Binding to soluble and membrane-bound IL-6 receptors
- Inhibition of IL-6-mediated signaling
Dosage & Administration
- Intravenous infusion
- Monotherapy or concomitant use with other drugs
- Dosage based on body weight
- Schedule based on condition
- Subcutaneous injection for some conditions
- Max dosage in COVID-19 patients
- Dosage reduction for certain laboratory abnormalities
- Dilution for intravenous administration
Interaction
- Coadministration with CYP3A4 substrates
- Effect on CYP450 enzyme activity
Contraindications
- Known hypersensitivity to Tocilizumab
Side Effects
- Upper respiratory tract infections
- Headache
- Hypertension
- Increased ALT
- Injection site reactions
- Constipation
- Anxiety
- Diarrhea
- Insomnia
- Nausea
Pregnancy & Lactation
- Potential fetal harm
- Consideration for COVID-19 treatment during pregnancy
- Breastfeeding precautions for COVID-19
Precautions & Warnings
- Serious Infections
- Tuberculosis evaluation
- Gastrointestinal perforation risk
- Hepatotoxicity monitoring
- Laboratory monitoring
- Hypersensitivity reactions
- Avoidance of live vaccines
- Avoidance of biological DMARDs
- ANC, platelet count, ALT or AST level restrictions
Use in Special Populations
- Pediatric use limitations
- Elderly caution
- Hepatic impairment considerations
- Renal impairment considerations
Overdose Effects
- Monitoring for adverse reactions
- Symptomatic treatment for adverse reactions
Therapeutic Class
- Drugs used for Rheumatoid Arthritis
Storage Conditions
- Temperature range for storage
- Avoid freezing