Lispril 5 mg (Tablet)
Unit Price: ৳ 2.25 (50's pack: ৳ 112.50)
Medicine Details
| Category | Details |
|---|---|
| Generic | Lisinopril |
| Company | Medimet pharmaceuticals ltd |
Indications
- Treatment of hypertension in adult patients
- Treatment of hypertension in pediatric patients 6 years and older
- Lowering blood pressure to reduce cardiovascular events
- Treatment of heart failure to reduce signs and symptoms
- Reduction of mortality in treatment of hemodynamically stable patients within 24 hours of acute myocardial infarction
Pharmacology
- Competitive inhibition of ACE
- Inhibition of conversion of angiotensin I to angiotensin II
- Increase in plasma renin activity
- Reduction in aldosterone secretion
- Promotion of vasodilation
- Blood pressure reduction
Dosage
- Initial dose of 10 mg/day for hypertension in adults
- Initial dose of 2.5-5 mg for patients with renovascular hypertension or volume depletion
- Initial dose of 5 mg/day for patients on diuretics
- Dosage maintenance up to 80 mg/day if needed
- Initial dose of 10 mg/day for hypertensive type 2 diabetics with microalbuminuria
- Initial dose of 2.5 or 5 mg/day for heart failure
Administration
- May be taken with or without food
Interaction
- Enhancement of hypotensive effect with diuretics
- Increased risk of renal function deterioration and decreased antihypertensive effect with NSAIDs
- Increased serum levels and toxicity of lithium
- Increased risk of hyperkalaemia with K-sparing diuretics and K supplements
- Increase in nitritoid reactions of gold Na thiomalate
Contraindications
- History of angioedema related to previous ACE inhibitor treatment
- Hereditary or idiopathic angioedema
- Concomitant use with aliskiren in patients with diabetes or renal impairment
- Pregnancy
- Children with GFR <30 mL/min/1.73 m2
Side Effects
- Headache
- Fatigue
- Persistent and non-productive cough
- Chest and abdominal pain
- Dizziness
- Nausea
- Vomiting
- Diarrhoea
- Hypotension
- Renal dysfunction
- Hyperkalaemia
- Intestinal angioedema
- Increased BUN and serum creatinine levels
Pregnancy & Lactation
- Category D drug
- Positive evidence of human foetal risk
- Acceptable benefits in pregnant women despite the risk
Precautions & Warnings
- Bilateral renal artery stenosis or a single kidney with unilateral renal artery stenosis
- Collagen vascular disease
- Acute MI at risk of further haemodynamic deterioration
- Angioedema unrelated to ACE inhibitor therapy
- Aortic stenosis
- Hypertrophic cardiomyopathy
- Increased risk of angioedema in black patients
- Renal impairment
- Lactation
- Children under 6 years old
Use in Special Populations
- Adults with CrCl 10-30 ml/min
- Adults with CrCl 31-80 ml/min
- Children with GFR <30 mL/min/1.73 m2
Overdose Effects
- Hypotension
- Tachycardia
- Circulatory shock
- Electrolyte disturbances
- Anxiety
- Dizziness
- Cough
Therapeutic Class
- Angiotensin-converting enzyme (ACE) inhibitors
Storage Conditions
- Store at below 25°C