Sergel 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 7.00 (10 x 10: ৳ 700.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Esomeprazole
Company Healthcare pharmaceuticals ltd
Also available as
Sergel 20 mg capsule Sergel 40 mg capsule Sergel 40 mg injection Sergel 40 mg tablet Sergel 20 mg powder

Title

  • Sergel 20 mg Tablet

Categories

  • Heartburn Relief
  • Gastroesophageal Reflux Disease (GERD) Treatment
  • Erosive Esophagitis Healing
  • Helicobacter Pylori Infection Eradication
  • Zollinger-Ellison Syndrome Treatment
  • Acid-related Dyspepsia Relief
  • Duodenal & Gastric Ulcer Healing

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment of Zollinger-Ellison Syndrome
  • Relief from acid-related Dyspepsia
  • Healing of duodenal and gastric ulcers

Pharmacology

  • Proton pump inhibitor
  • Specific inhibition of the H/K-ATPase in the gastric parietal cell
  • Provides better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation of esomeprazole magnesium
  • Peak plasma levels at approximately 1.5 hours
  • Plasma protein binding constant over 2-20mmol/L
  • Extensively metabolized in the liver by the CYP enzyme system
  • Plasma elimination half-life of approximately 1-1.5 hours
  • Combination therapy with antimicrobials (clarithromycin and amoxicillin)

Dosage

  • Healing of Erosive Esophagitis: 20mg or 40mg once daily for 4-8 weeks
  • Maintenance of Healing of Erosive Esophagitis: 20mg once daily
  • Symptomatic GERD: 20mg once daily for 4 weeks
  • Helicobacter Pylori eradication: Triple Therapy for 10 days
  • Zollinger-Ellison Syndrome: 20-80mg once daily
  • Acid-related Dyspepsia: 20-40mg once daily for 2-4 weeks
  • Duodenal Ulcer: 20mg once daily for 2-4 weeks
  • Gastric Ulcer: 20-40mg once daily for 4-8 weeks
  • IV Injection/Infusion for various conditions and age groups

Administration

  • Tablet/capsule: Swallowed whole, taken 1 hour before a meal
  • Oral Suspension: Preparing and administering instructions
  • IV Injection: Preparation and administration guidelines

Interaction

  • Metabolized by CYP2C19 and CYP3A4
  • Inhibition of CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4 not likely
  • No clinically relevant interactions with certain drugs
  • Potential interference with the absorption of specific drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects in animal studies
  • Excretion in milk not studied; breastfeeding discontinuation recommended

Precautions warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Instructions for patients on capsule swallowing and administration with applesauce
  • Use of antacids while taking Sergel

Special populations

  • Safety and effectiveness in pediatric patients not established
  • No overall differences in safety and efficacy between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose effects

  • Signs of acute toxicity in rats
  • No specific antidote known
  • Symptomatic and supportive treatment recommended

Storage conditions

  • Store at a temperature not exceeding 30°C
  • Dry place, protected from light and moisture
  • Keep out of reach of children

Chemical structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure: Image of Esomeprazole molecular structure

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