Esoral MUPS 40 mg (MUPS Tablet)

Unit Price: ৳ 14.00 (5 x 6: ৳ 420.00)
Strip Price: ৳ 84.00

Medicine Details

Category Details
Generic Esomeprazole mups preparation
Company Eskayef pharmaceuticals ltd
Also available as
Esoral mups 20 mg tablet

Title

  • Esoral MUPS 20 Tablet
  • Esoral MUPS 40 Tablet

Categories

  • Medicine
  • Pharmaceutical Product

Indications

  • Gastro-esophageal Reflux Disease (GERD)
  • Risk reduction in NSAID associated gastric ulcer
  • H. pylori eradication (Triple therapy)
  • Zollinger-Ellison syndrome and idiopathic hypersecretion

Composition

  • 20 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)
  • 40 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)

Description

  • MUPS is abbreviation for Multiple-Unit Pellet System
  • Greater bioavailability
  • Uniform emptying of micro pellets from stomach into small intestine facilitates rapid dissolution
  • Lesser possibility of dose dumping
  • Combines fast acting and sustained action
  • Uniform drug release
  • Once daily dosing
  • Lesser chance of localized irritation
  • Better and more uniform drug absorption
  • Reduces the esophageal residence time
  • Minimizes fluctuation in plasma concentration of drug

Mode of Action

  • Inhibits gastric acid by blocking the hydrogen-potassium adenosine triphosphatase enzyme system

Dosage

  • Adult (≥18 years): 40 mg once daily for 4 weeks
  • Children & adolescents (12-18 years): 40 mg once daily for 4 weeks
  • Adult (≥18 years): 20 mg once daily
  • Children & adolescents (12-18 years): 20 mg once daily
  • Adult (≥18 years): 20 mg once daily for 4-8 weeks
  • Adult (≥18 years): 20 mg twice daily for 7 days
  • Children & adolescents (12-18 years): 20 mg twice daily for 7 days
  • Adult (≥18 years): 40-80 mg twice daily
  • Children 1-11 years: Weight <20 kg: 10 mg once daily for 8 weeks, Weight ≥20 kg: 10 mg or 20 mg once daily for 8 weeks
  • Maintenance of healing of erosive esophagitis: 10 mg once daily

Administration

  • Should be swallowed whole with liquid
  • Dispersed in half a glass of non-carbonated water if required
  • Pellets must not be chewed or crushed

Interaction

  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
  • May interfere with CYP2C19, the major metabolizing enzyme
  • Inhibits gastric acid secretion
  • Co-administration with diazepam resulted in decreased clearance
  • May interfere with absorption of drugs where gastric pH is important
  • No significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxicillin

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • Manufacturer advises caution

Precautions & Warnings

  • Should be used carefully if the patient has severe liver dysfunction and severe renal impairment
  • May slightly increase the risk of hip, wrist and spine fracture

Storage Conditions

  • Cool & dry place below 25°C
  • Protect from light
  • Keep out of reach of children

Chemical Structure

  • C17H19N3O3S

Commonly Asked Questions

  • Relieves heartburn and GERD symptoms
  • Heals erosive esophagitis
  • Prevents erosive esophagitis recurrence
  • May cause common side effects like headaches, diarrhea, nausea, gas, stomach pain, constipation, and dry mouth

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