Pronex 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (5 x 10: ৳ 350.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Esomeprazole
Company Drug international ltd
Also available as
Pronex 20 mg tablet Pronex 40 mg tablet Pronex 40 mg injection Pronex 40 mg capsule

Title

Pronex 20 mg Capsule

Categories

  • Medicine
  • Gastrointestinal Health
  • Heartburn Relief
  • Acid Reducer
  • Proton Pump Inhibitor

Description

Pronex 20 mg Capsule is a proton pump inhibitor (PPI) used to relieve chronic heartburn symptoms, heal erosive esophagitis, maintain healing of erosive esophagitis, eradicate Helicobacter pylori infection, treat Zollinger-Ellison Syndrome, acid-related Dyspepsia, duodenal & gastric ulcers, and reduce the risk of rebleeding of gastric or duodenal ulcers.

Dimensions

N/A

ColorOptions

  • N/A

Functions

  • Relieves chronic heartburn symptoms
  • Heals erosive esophagitis
  • Maintains healing of erosive esophagitis
  • Eradicates Helicobacter pylori infection
  • Treats Zollinger-Ellison Syndrome
  • Manages acid-related Dyspepsia
  • Treats duodenal & gastric ulcers
  • Reduces risk of rebleeding of gastric or duodenal ulcers

Materials

  • N/A

TechnicalSpecifications

  • DosageForm: Oral capsule
  • DosageStrength: 20 mg
  • AdministrationInstructions: Swallow whole, take one hour before meal
  • StorageConditions: Store at a temperature not exceeding 30°C in a dry place, protect from light and moisture, keep out of reach of children
  • OverdoseEffects: A single oral dose of Pronex at 510 mg/kg has been lethal to rats, and the major signs of acute toxicity include reduced motor activity, changes in respiratory frequency, tremor, ataxia, and intermittent clonic convulsions. No specific antidote for Pronex is known. Treatment should be symptomatic and supportive.

DesignElements

  • Enteric-coated pellet formulation
  • Clear and colorless to very slightly yellow IV injection solution

UsabilityFeatures

  • Well-tolerated medicine
  • Quick relief
  • Long-term use provides relief for a longer duration

Absorption

  • PeakPlasmaLevels: Cmax occurs at approximately 1.5 hours after oral administration
  • Bioavailability: Approximately 90% at steady state, decreased by 33-53% after food intake
  • ProteinBinding: 97%

Metabolism

  • Route: Liver
  • EnzymeSystem: Cytochrome P450 (CYP) enzyme system

Excretion

  • PlasmaEliminationHalfLife: Approximately 1–1.5 hours
  • ExcretionRoute: Less than 1% in urine, approximately 80% as inactive metabolites in urine, and the remainder in feces

CombinationTherapy

  • TripleTherapy: Esomeprazole 40 mg once daily, clarithromycin 500 mg twice daily, and amoxicillin 1000 mg twice daily for 7 days

Interactions

  • Metabolism: Extensively metabolized by CYP2C19 and CYP3A4
  • Inhibition:
    • Expected: Pronex is not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
    • PotentialEffects: May interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability
  • Co-administration:
    • Phenytoin
    • Warfarin
    • Quinidine
    • Clarithromycin
    • Amoxicillin
    • Diazepam
    • Oral contraceptives

Contraindications

  • Known hypersensitivity to any of the formulation

SideEffects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

PregnancyAndLactation

  • Pregnancy: No adequate and well-controlled studies in pregnant women
  • Lactation: Excretion in milk not studied, breastfeeding should be discontinued if use is considered essential

PrecautionsAndWarnings

  • Symptomatic response to therapy does not preclude presence of gastric malignancy
  • Antacids may be used while taking Pronex

SpecialPopulations

  • PediatricUse: Safety and effectiveness not established
  • GeriatricUse: No overall differences in safety and efficacy observed between the elderly and younger individuals

ChemicalStructure

  • MolecularFormula: C17H19N3O3S
  • ChemicalImageURL: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

CommonlyAskedQuestions

  • WhatIsItUsedFor: Pronex 20 mg Capsule is a proton pump inhibitor used to treat GERD, ulcers, and other conditions involving excess stomach acid
  • SideEffects: Headaches, diarrhea, nausea, flatulence, abdominal pain, constipation, dry mouth
  • PregnancyAndBreastfeeding: Consult doctor about risks and benefits if pregnant or breastfeeding
  • OnsetOfWork: Usually starts to work within a few hours of taking it

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