Onepro 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.00 (6 x 10: ৳ 480.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Esomeprazole
Company One pharma ltd
Also available as
Onepro 20 mg tablet Onepro 40 mg capsule Onepro 40 mg tablet

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment of Zollinger-Ellison Syndrome
  • Management of Acid-related Dyspepsia
  • Treatment of Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • Peak plasma levels occur at approximately 1.5 hours after oral administration
  • Metabolized in the liver by the cytochrome P450 enzyme system
  • Plasma protein binding is constant over the concentration range

Dosage

  • 20 mg or 40 mg once daily for healing of erosive esophagitis
  • 20 mg once daily for maintenance of healing of erosive esophagitis
  • 10-day triple therapy for Helicobacter pylori eradication
  • 20-80 mg once daily for Zollinger-Ellison Syndrome
  • 20-40 mg once daily for Acid-related Dyspepsia
  • 20 mg once daily for 2-4 weeks for Duodenal ulcer
  • 20-40 mg once daily for 4-8 weeks for Gastric ulcer
  • Dosage for pediatric patients based on body weight

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral suspension should be taken after mixing with water
  • IV injection or IV infusion as per specified guidelines

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • No clinically relevant interactions with certain CYP enzymes
  • Potential interference with the absorption of drugs where gastric pH is important
  • No significant interactions with specific drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects observed in animal studies
  • Excretion in milk not studied
  • Breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Instructions for patients regarding capsule administration and use of antacids

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • No overall differences in safety and efficacy observed between elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Lethal dose observed in rats at a significantly high dosage
  • No specific antidote known
  • Treatment should be symptomatic and supportive

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions

  • Purpose, uses, and side effects of Onepro 20 mg Capsule
  • Administration in pregnant or breastfeeding individuals
  • Onset of action and quick tips for usage

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