Esobest 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (6 x 10: ৳ 420.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Esomeprazole
Company Sharif pharmaceuticals ltd
Also available as
Esobest 20 mg tablet Esobest 40 mg capsule Esobest 40 mg tablet Esobest 40 mg injection

Indications

  • To relieve from chronic heartburn symptoms and other symptoms associated with GERD
  • For the healing of erosive esophagitis
  • For maintenance of healing of erosive esophagitis
  • In combination with amoxicillin and clarithromycin for eradication of Helicobacter pylori infection in patients with duodenal ulcer disease.
  • Zollinger-Ellison Syndrome
  • Acid related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell.
  • Esomeprazole (S-isomer of omeprazole) provides better acid control than racemic proton pump inhibitors.
  • Absorption: Esomeprazole capsules contain an enteric-coated pellet formulation of esomeprazole magnesium. Peak plasma levels (Cmax) occur at approximately 1.5 hours.
  • Systemic bioavailability is approximately 90% compared to 64% after a single dose. The AUC after administration of a single dose of esomeprazole is decreased by 33-53% after food intake compared to fasting conditions.
  • Distribution: Esomeprazole is 97% bound to plasma proteins. The apparent volume of distribution at steady state in healthy volunteers is approximately 16 L.
  • Metabolism: Esomeprazole is extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system.
  • Excretion: The plasma elimination half-life of esomeprazole is approximately 1–1.5 hours.
  • Combination Therapy with Antimicrobials: Esomeprazole magnesium 40 mg once daily is given in combination with clarithromycin 500 mg twice daily and amoxicillin 1000 mg twice daily for 7 days.

Dosage

  • Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks. The majority of patients are healed within 4 to 8 weeks.
  • For maintenance of healing of erosive esophagitis: 20 mg Once Daily
  • Symptomatic GERD: 20 mg Once Daily for 4 Weeks
  • Helicobacter Pylori eradication: Esomeprazole 40 mg Once Daily for 10 days, Amoxicillin 1000 mg Twice Daily for 10 days, Clarithromycin 500 mg Twice Daily for 10 days.
  • Zollinger-Ellison Syndrome: The dose is 20-80 mg once daily.
  • Acid-related Dyspepsia: 20-40 mg once daily for 2-4 weeks according to the response.
  • Duodenal ulcer: 20 mg once daily for 2-4 weeks. Gastric ulcer: 20-40 mg once daily for 4-8 weeks.
  • IV Injection or IV infusion: Adult Patients (≥18 years): 20 mg or 40 mg once daily. Pediatric Patients: Body weight <55 kg: 10 mg Once daily, Body Weight ≥55 kg: 20 once daily.

Administration

  • Tablet or capsule: should be swallowed whole and taken one hour before a meal.
  • Oral Suspension: The mixer should be stirred well and leave 2 to 3 minutes to thicken. Drink within 30 minutes.
  • IV Injection: Must be administered intravenously over a period of at least 3 minutes.

Interactions

  • No clinically relevant interactions with drugs metabolized by CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4 would be expected.
  • Esobest may potentially interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability.

Contraindications

  • Esomeprazole is contraindicated in-patient with known hypersensitivity to any of the formulation.

Side Effects

  • Common adverse events reported with Esobest include headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth.

Pregnancy & Lactation

  • There are no adequate and well-controlled studies in pregnant women.
  • The excretion of esomeprazole in milk has not been studied.

Precautions & Warnings

  • Symptomatic response to therapy with Esobest does not preclude the presence of gastric malignancy.
  • Esobest capsules should be taken at least one hour before meals.

Use in Special Populations

  • Safety and effectiveness in paediatric patients have not been established.
  • No overall differences in safety and efficacy have been observed between the elderly and younger individuals.
  • No dosage adjustment is recommended for patients with mild to moderate hepatic insufficiency.
  • The Pharmacokinetics of Esobest in patients with renal impairment are not expected to be altered relative to healthy volunteers.

Overdose Effects

  • No specific antidote for Esobest is known. Treatment should be symptomatic and supportive.

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.

Chemical Structure

  • Molecular Formula : C17H19N3O3S

Common Questions about Esobest 20 mg Capsule

  • Esobest 20 mg Capsule is a proton pump inhibitor (PPI).
  • Esobest 20 mg Capsule is used to treat gastroesophageal reflux disease (GERD), ulcers, and other conditions that involve too much stomach acid.
  • Esobest 20 mg Capsule may cause common side effects like headaches, diarrhea, nausea, gas, stomach pain, constipation, and dry mouth.
  • Esobest 20 mg Capsule doesn't have any side-effects if you are pregnant or breastfeeding.
  • Esobest 20 mg Capsule usually starts to work within a few hours of taking it.

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