Esomups 20 mg (MUPS Tablet)

Unit Price: ৳ 11.00 (10 x 6: ৳ 660.00)
Strip Price: ৳ 66.00

Medicine Details

Category Details
Generic Esomeprazole mups preparation
Company Jenphar bangladesh ltd
Also available as
Esomups 40 mg tablet

Indications

  • Gastro-esophageal Reflux Disease (GERD)
  • Risk reduction in NSAID associated gastric ulcer
  • H. pylori eradication (Triple therapy)
  • Zollinger-Ellison syndrome and idiopathic hypersecretion

Composition

  • Esomeprazole MUPS 20 Tablet: 20 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)
  • Esomeprazole MUPS 40 Tablet: 40 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)

Description

  • MUPS is abbreviation for Multiple-Unit Pellet System
  • Greater bioavailability
  • Uniform emptying of micro pellets from stomach into small intestine
  • Lesser possibility of dose dumping
  • Combination of fast acting and sustained action
  • Uniform drug release
  • Once daily dosing
  • Rapid and uniform gastric emptying
  • Uniform drug absorption
  • Better than capsules in reducing the esophageal residence time
  • Minimizes fluctuation in plasma concentration of drug

Pharmacology

Inhibits gastric acid by blocking the hydrogen-potassium adenosine triphosphatase enzyme system (the proton pump) of the gastric parietal cell

Dosage

  • Erosive esophagitis:
    • Adult (≥18 years): 40 mg once daily for 4 weeks
    • Children & adolescents (12-18 years): 40 mg once daily for 4 weeks
  • Maintenance of healing of erosive esophagitis:
    • Adult (≥18 years): 20 mg once daily
    • Children & adolescents (12-18 years): 20 mg once daily
  • Risk reduction in NSAID associated gastric ulcer: 20 mg once daily for 4-8 weeks
  • H. pylori eradication (Esomeprazole MUPS tablet with 1000 mg Amoxicillin and 500 mg Clarithromycin):
    • Adult (≥18 years): 20 mg twice daily for 7 days
    • Children & adolescents (12-18 years): 20 mg twice daily for 7 days
  • Zollinger-Ellison syndrome and idiopathic hypersecretion: 40-80 mg twice daily
  • Children 1-11 years:
    • Erosive esophagitis: Weight < 20 kg: 10 mg once daily for 8 weeks, Weight ≥ 20 kg: 10 mg or 20 mg once daily for 8 weeks
    • Maintenance of healing of erosive esophagitis: 10 mg once daily
  • Children below the age of 1 year: Esomeprazole MUPS tablet is not approved for use in children younger than 1 year

Administration

Tablets should be swallowed whole with liquid; can also be dispersed in non-carbonated water if required

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
  • No clinically relevant interactions with drugs metabolized by these CYP enzymes
  • May potentially interfere with CYP2C19
  • Co-administration with diazepam resulted in a 45% decrease in clearance of diazepam
  • May interfere with the absorption of drugs where gastric pH is important
  • Co-administration of oral contraceptives, diazepam, phenytoin, or quinidine do not seem to change the pharmacokinetic profile of Esomups
  • Combination Therapy with Clarithromycin increases the plasma levels of Esomups and 14-hydroxyclarithromycin

Contraindications

Contraindicated in patient with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

Manufacturer advises caution; not known if Esomeprazole or its metabolites appear in human breast milk

Precautions & Warnings

  • Use cautiously with severe liver dysfunction and severe renal impairment
  • May slightly increase the risk of hip, wrist and spine fracture if taken over a period of more than one year

Storage Conditions

Store in a cool & dry place below 25°C, protect from light

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

Common Questions

  • What is Esomups 20 mg MUPS Table?: Used to treat gastroesophageal reflux disease (GERD), ulcers, and other conditions that involve too much stomach acid
  • What is MUPS Tablet?: Abbreviation for Multiple-Unit Pellet System; tablets prepared by compaction of modified release coated multiparticulates or pellets
  • What is Esomups 20 mg MUPS Table used for?: Relieves heartburn, GERD symptoms, and aids in healing erosive esophagitis; prevents erosive esophagitis recurrence
  • What are the side effects of Esomups 20 mg MUPS Table?: Headaches, diarrhea, nausea, gas, stomach pain, constipation, dry mouth
  • Can I take Esomups 20 mg MUPS Table if I am pregnant or breastfeeding?: Doesn't have any side-effects if you are pregnant or breastfeeding; talk to your doctor about the risks and benefits
  • How long does it take for Esomups 20 mg MUPS Table to work?: Usually starts to work within a few hours of taking it
  • Quick Tips:
    • Well-tolerated medicine providing long-term relief
    • Avoid eating late at night or before bedtime
    • Inform your doctor if you get watery diarrhea, fever, or stomach pain
    • Long-term use can cause weak bones and mineral deficiency
    • Consult your doctor right away if you develop specific symptoms

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