Esover 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.02 (6 x 10: ৳ 421.20)
Strip Price: ৳ 70.20

Medicine Details

Category Details
Generic Esomeprazole
Company Veritas pharmaceuticals ltd
Also available as
Esover 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • First single optical isomer of proton pump inhibitor
  • Better acid control than racemic proton pump inhibitors
  • High bioavailability
  • Extensive metabolism in the liver
  • Metabolized by cytochrome P450 enzyme system
  • Excretion mainly as inactive metabolites
  • Combination therapy with antimicrobials

Dosage

  • Oral dosage form
  • IV Injection or IV infusion
  • Different dosages for different indications
  • Pediatric dosage based on body weight
  • Different dosage for risk reduction of rebleeding of Gastric or Duodenal Ulcers

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension administration
  • IV Injection preparation and administration

Interactions

  • Metabolized by CYP2C19 and CYP3A4
  • No significant interactions with certain drugs
  • Potential interference with CYP2C19
  • Potential interference with absorption of specific drugs
  • No significant interactions with oral contraceptives, diazepam, phenytoin, or quinidine
  • Increased plasma levels with combination therapy

Contraindications

  • Known hypersensitivity

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies show no teratogenic effects
  • Excretion in milk not studied
  • Discontinuation of breastfeeding if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Instructions for patients regarding capsule administration
  • Use of antacids while taking Esomeprazole

Use in Special Populations

  • No established safety and effectiveness in pediatric patients
  • No overall differences in safety and efficacy in geriatric patients
  • No dosage adjustment needed for mild to moderate hepatic insufficiency
  • No dosage adjustment needed for renal insufficiency

Overdose Effects

  • Lethal dose in rats
  • Signs of acute toxicity
  • No specific antidote known
  • Symptomatic and supportive treatment

Storage Conditions

  • Temperature and moisture restrictions
  • Protection from light
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions about Esover 20 mg Capsule

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