Esomium 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 6.00 (7 x 10: ৳ 420.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Esomeprazole
Company Jenphar bangladesh ltd
Also available as
Esomium 40 mg capsule

Product Title

  • Esomium 20 mg Capsule

Categories

  • Medicine
  • Gastric Health
  • Proton Pump Inhibitor

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment of Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Treatment for Duodenal & Gastric ulcer

Mode of Action

  • Proton pump inhibitor that suppresses gastric acid secretion
  • Inhibition of the H+/K+-ATPase in the gastric parietal cell
  • Better acid control than racemic proton pump inhibitors
  • Absorption through enteric-coated pellet formulation of esomeprazole magnesium
  • Extensive metabolism in the liver by cytochrome P450 (CYP) enzyme system
  • Plasma protein binding constant over a certain concentration range
  • Excretion primarily through inactive metabolites in urine and faeces

Dosage Form

  • Oral capsule
  • Oral suspension
  • IV Injection or IV infusion

Dosage Guidelines

  • Multiple dosage options for specific conditions and patient demographics

Administration Instructions

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Instructions for oral suspension administration
  • Preparation of IV Injection solution
  • Reconstitution and administration of IV infusion solution

Drug Interactions

  • Metabolized by CYP2C19 and CYP3A4
  • Inhibition of gastric acid secretion may affect drug absorption (e.g., ketoconazole, iron salts, digoxin)
  • Co-administration impact on diazepam clearance and plasma levels
  • Co-administration with clarithromycin alters plasma levels of esomeprazole and 14-hydroxyclarithromycin

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No excretion studies, breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response does not rule out gastric malignancy
  • Instructions for patients with difficulty swallowing capsules
  • Use of antacids while taking Esomium

Special Populations Use

  • Safety and effectiveness in paediatric patients not established
  • No overall differences in safety and efficacy for elderly individuals
  • No dosage adjustment for mild to moderate hepatic insufficiency

Overdose Effects

  • Symptoms of acute toxicity in animal studies
  • No specific antidote known, treatment should be symptomatic and supportive
  • Not expected to be removed by dialysis

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protection from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure diagram

Commonly Asked Questions

  • Information about uses, side effects, pregnancy & breastfeeding, onset of action, and quick tips

Other Useful Information

  • Information on different uses and conditions like gastric ulcers, Zollinger-Ellison Syndrome, and duodenal ulcers

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