Esonaaf 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.00 (6 x 10: ৳ 480.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Esomeprazole
Company Naafco pharma ltd
Also available as
Esonaaf 40 mg capsule

Title

Esonaaf 20 mg Capsule

Categories

  • Medicine
  • Proton Pump Inhibitor
  • Gastrointestinal Health

Description

Esonaaf 20 mg Capsule is indicated for the relief of chronic heartburn symptoms, healing of erosive esophagitis, maintenance of healing of erosive esophagitis, eradication of Helicobacter pylori infection, treatment of Zollinger-Ellison Syndrome, acid related dyspepsia, duodenal and gastric ulcers. It is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. Esonaaf is available in oral dosage form and IV injection or infusion for various indications. It is contraindicated in patients with known hypersensitivity to any of the formulation.

Attributes

  • Indications:
    • Relief from chronic heartburn symptoms
    • Healing of erosive esophagitis
    • Maintenance of healing of erosive esophagitis
    • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
    • Treatment of Zollinger-Ellison Syndrome
    • Acid-related Dyspepsia
    • Treatment of duodenal and gastric ulcers
  • Pharmacology:
    • Suppresses gastric acid secretion
    • Specific inhibition of the H+/K+-ATPase
    • Provision of better acid control than racemic proton pump inhibitors
    • Plasma protein binding is constant over the concentration range
    • Extensively metabolized in the liver
    • Plasma elimination half-life of approximately 1-1.5 hours
    • Triple therapy with clarithromycin and amoxicillin increases steady state AUC and Cmax of esomeprazole
  • Dosage:
    • 20 mg or 40 mg once daily for healing of erosive esophagitis
    • 20 mg once daily for 4-8 weeks for maintenance of healing of erosive esophagitis
    • 20 mg once daily for symptomatic GERD
    • 40 mg once daily for Helicobacter pylori eradication
    • 20-80 mg once daily for Zollinger-Ellison Syndrome
    • 20-40 mg once daily for acid-related dyspepsia
    • 20 mg once daily for 2-4 weeks for duodenal ulcer
    • 20-40 mg once daily for 4-8 weeks for gastric ulcer
    • Different dosages for adult and pediatric patients
  • Administration:
    • Tablet or capsule should be swallowed whole and taken one hour before a meal
    • Reconstituted solution for IV injection must be used within 12 hours of preparation
    • Different administration procedures for oral suspension and IV injection
  • Interaction:
    • Extensively metabolized by CYP2C19 and CYP3A4
    • Not likely to inhibit certain CYP enzymes
    • May interfere with the absorption of drugs where gastric pH is important for bioavailability
  • Contraindications:
    • Known hypersensitivity to any of the formulation
  • Side Effects:
    • Headache
    • Diarrhoea
    • Nausea
    • Flatulence
    • Abdominal pain
    • Constipation
    • Dry mouth
  • Pregnancy & Lactation:
    • No adequate and well-controlled studies in pregnant women
    • Animal studies have revealed no teratogenic effects
    • Excretion of esomeprazole in milk not studied
    • Breastfeeding should be discontinued if esomeprazole use is essential
  • Precautions & Warnings:
    • Symptomatic response to therapy does not preclude the presence of gastric malignancy
    • Specific instructions for patients with difficulty swallowing capsules
    • Use of antacids while taking Esonaaf
  • Use in Special Populations:
    • Safety and effectiveness not established in pediatric patients
    • No overall differences in safety and efficacy observed between elderly and younger individuals
    • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
    • Pharmacokinetics not expected to be altered in renal impairment
  • Overdose Effects:
    • Signs of acute toxicity in animal studies
    • No specific antidote known
    • Symptomatic and supportive treatment recommended
  • Storage Conditions:
    • Store at a temperature not exceeding 30°C
    • Protect from light and moisture
    • Keep out of reach of children
  • Commonly Asked Questions:
    • Overview of Esonaaf 20 mg Capsule
    • Multiple uses of Esonaaf 20 mg Capsule
    • Common side effects of Esonaaf 20 mg Capsule
    • Considerations for pregnant or breastfeeding individuals
    • Onset of action and quick tips for taking Esonaaf 20 mg Capsule
  • Chemical Structure:
    • Molecular Formula: C<sub>17</sub>H<sub>19</sub>N<sub>3</sub>O<sub>3</sub>S
    • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

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