Esozol 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (6 x 10: ৳ 420.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Esomeprazole
Company Medicon pharmaceuticals ltd
Also available as
Esozol 20 mg tablet Esozol 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms and symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • Absorption peak plasma levels occur at approximately 1.5 hours
  • Metabolized in the liver by the cytochrome P450 (CYP) enzyme system
  • Plasma elimination half-life of approximately 1–1.5 hours

Dosage

  • For healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
  • 20 mg Once Daily for maintenance of healing of erosive esophagitis
  • 20 mg Once Daily for Symptomatic GERD for 4 Weeks
  • Triple Therapy for Helicobacter Pylori eradication
  • 20-80 mg once daily for Zollinger-Ellison Syndrome
  • 20-40 mg once daily for Acid-related Dyspepsia for 2-4 weeks
  • 20 mg once daily for 2-4 weeks for Duodenal ulcer and 20-40 mg once daily for 4-8 weeks for Gastric ulcer
  • IV Administration for adults - 20 mg or 40 mg once daily
  • IV Administration for pediatric patients based on body weight
  • 80 mg IV infusion for risk reduction of rebleeding of Gastric or Duodenal Ulcers following therapeutic endoscopy in adults

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension administration instructions
  • IV Injection administration and storage instructions

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • No clinically relevant interactions with certain drugs
  • Potential interference with the absorption of drugs where gastric pH is important

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No well-controlled studies in pregnant women
  • No studies on excretion in milk
  • Breast-feeding should be discontinued if esomeprazole use is essential

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Oral administration instructions for patients

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • No overall differences in safety and efficacy between elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • No alterations in pharmacokinetics in patients with renal impairment

Overdose Effects

  • Signs of acute toxicity in rats
  • No reports of overdose
  • No specific antidote known
  • Management should be symptomatic and supportive

Storage Conditions

  • Temperature not exceeding 30°C
  • Dry place
  • Protection from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Commonly Asked Questions

  • Explanation of Esozol 20 mg Capsule
  • Uses of Esozol 20 mg Capsule
  • Side effects of Esozol 20 mg Capsule
  • Use during pregnancy or breastfeeding
  • Time for Esozol 20 mg Capsule to work
  • Quick Tips for using Esozol 20 mg Capsule

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