Exome 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 7.00 (10 x 10: ৳ 700.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Esomeprazole
Company Chemist laboratories ltd

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment of Zollinger-Ellison Syndrome
  • Treatment of acid-related Dyspepsia
  • Treatment of duodenal & gastric ulcers

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Enteric-coated pellet formulation
  • Peak plasma levels at approximately 1.5 hours
  • Metabolized in the liver by the cytochrome P450 enzyme system

Dosage

  • 20 mg or 40 mg once daily for healing of erosive esophagitis
  • 20 mg once daily for maintenance of healing of erosive esophagitis
  • 20 mg once daily for symptomatic GERD
  • 40 mg once daily for Helicobacter pylori eradication
  • 20-80 mg once daily for Zollinger-Ellison Syndrome
  • 20-40 mg once daily for acid-related Dyspepsia

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral suspension should be stirred well and consumed within 30 minutes
  • IV injection must be administrated intravenously over a period of at least 3 minutes

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
  • May interfere with the absorption of drugs where gastric pH is important for bioavailability
  • May potentially interfere with CYP2C19, the major metabolizing enzyme

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies have revealed no teratogenic effects
  • Excretion in milk not studied
  • Breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Capsules should be taken at least one hour before meals

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • No overall differences in safety and efficacy between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • No alteration in pharmacokinetics in patients with renal impairment

Overdose Effects

  • Acute toxicity signs include reduced motor activity, changes in respiratory frequency, tremor, and convulsions
  • No specific antidote known
  • Treatment should be symptomatic and supportive

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions about Exome 20 mg Tablet

  • Proton pump inhibitor used for treating GERD, ulcers, and conditions involving excessive stomach acid
  • Common side effects include headache, diarrhea, nausea, and stomach pain
  • No significant side effects for pregnant or breastfeeding individuals
  • Typically starts working within a few hours of consumption
  • Tips for long-term use and potential side effects

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