Carceva 75 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clopidogrel bisulphate |
| Company | Nipro jmi pharma ltd |
Indications
- Reduce rate of myocardial infarction
- Reduce rate of stroke
- Non-ST-segment elevation ACS
- Unstable angina
- NSTEMI
- Acute ST-elevation myocardial infarction
- Recent MI
- Recent Stroke
- Established Peripheral Arterial Disease
Pharmacology
- Prodrug
- Inhibits platelet activation
- Irreversible binding to P2Y12 ADP receptors
- Dose-dependent inhibition of platelet aggregation
- Inhibition onset after 2 hours
- Steady state inhibition between Day 3 and Day 7
Dosage & Administration
- 300 mg oral loading dose for acute coronary syndrome
- 75 mg once daily orally for recent MI, Stroke, or Peripheral Arterial Disease
- Can be taken with or without food
Interactions
- Increased bleeding risk with NSAIDs, warfarin, SSRIs, SNRIs
- Avoid concomitant use with omeprazole or esomeprazole
- Increased plasma concentrations with Repaglinide concomitant use
Contraindications
- Hypersensitivity to the drug substance or any component
- Active pathological bleeding
Side Effects
- Common: Bleeding, Diarrhoea, gastrointestinal discomfort, Haemorrhage, Skin reactions
- Rare: Acquired haemophilia, Anaemia, Angioedema, Arthralgia, Arthritis, Bone marrow disorders
Pregnancy & Lactation
- Use only if clearly needed during pregnancy
- Unknown excretion in human breast milk
Precautions & Warnings
- Impaired metabolism by genetic variations in CYP2C19
- Increased bleeding risk due to lifetime platelet aggregation inhibition
- Discontinuation increases risk of cardiovascular events
- Reported cases of Thrombotic Thrombocytopenic Purpura (TTP)
- Reported cases of hypersensitivity reactions
Use in Special Populations
- Safety and effectiveness not established in pediatric populations
- No dosage adjustment necessary in elderly patients
Overdose Effects
- May lead to bleeding complications
- Platelet transfusion may restore clotting ability
Therapeutic Class
- Anti-platelet drugs
Storage Conditions
- Keep below 30°C in a dry place
- Protected from light
- Do not freeze
- Keep out of the reach of children