Dinosen 2 mg (Tablet)

Unit Price: ৳ 50.00 (3 x 10: ৳ 1,500.00)
Strip Price: ৳ 500.00

Medicine Details

Category Details
Generic Dienogest
Company Incepta pharmaceuticals ltd

Indications

  • Treatment of endometriosis
  • Reduction of pelvic pain in endometriosis

Pharmacology

  • Acts as an agonist at the progesterone receptor
  • Causes endometrial atrophy
  • Promotes antiproliferative, immunologic and antiangiogenic effects
  • Reduces endogenous production of oestradiol
  • Results in hyperprogestogenic and moderately hypoestrogenic endocrine environment
  • Antagonist at androgen receptors

Dosage & Administration

  • 2 mg daily dosage
  • Tablet-taking can be started on any day of the menstrual cycle
  • Continuous administration without regard to vaginal bleeding
  • Missed tablet instructions

Interaction

  • Metabolized mainly by the cytochrome P450 3A4 system
  • Influenced by CYP3A4 inhibitors and inducers

Contraindications

  • Hypersensitivity to dienogest or excipients
  • Active venous thromboembolic disorder
  • Arterial and cardiovascular disease
  • Diabetes mellitus with vascular involvement
  • Severe hepatic disease
  • Liver tumors (benign or malignant)
  • Known or suspected sex hormone-dependent malignancies
  • Undiagnosed vaginal bleeding

Side Effects

  • Headache
  • Breast discomfort
  • Depressed mood
  • Acne
  • Migraine
  • Palpitations
  • Nausea
  • Abdominal pain
  • Flatulence
  • Weight increase
  • Irritability
  • Nervousness
  • Altered mood

Pregnancy & Lactation

  • Limited data in pregnant women
  • No need to treat endometriosis during pregnancy
  • Not recommended during lactation
  • Excretion in breast milk

Precautions & Warnings

  • Exclusion of pregnancy before treatment
  • Use of nonhormonal methods of contraception during treatment
  • Impact on menstrual bleeding pattern
  • Contraindicated in patients with severe hepatic disease
  • Inhibition of ovulation

Use in Special Populations

  • Not indicated in children prior to menarche
  • Safety and efficacy in adolescents not established
  • No relevant indication for use in the geriatric population

Overdose Effects

  • No risk of acute adverse effects in case of inadvertent intake of multiple daily therapeutic dose

Therapeutic Class

  • Female Sex hormones

Storage Conditions

  • Keep in a cool and dry place
  • Protect from light
  • Keep out of the reach of children

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