Nebipro 2.5 mg (Tablet)

Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00

Medicine Details

Indications

  • Hypertension
  • Treatment of essential hypertension
  • Chronic heart failure (CHF)
  • Treatment of stable mild and moderate chronic heart failure in elderly patients.

Pharmacology

  • beta adrenergic receptor blocking agent
  • inhibits beta1 and beta1 adrenergic receptors
  • lacks intrinsic sympathomimetic and membrane stabilizing activity
  • decreased heart rate
  • decreased myocardia contractility
  • suppression of renin activity
  • vasodilation
  • metabolized by glucuronidation and hydroxylation by CYP2D6
  • active isomer has an effective half-life of about 12 hours in CYP2D6 extensive metabolizers
  • predominantly metabolized via direct glucuronidation
  • absorption similar to an oral solution
  • in vitro human plasma protein binding is approximately 98%

Dosage & Administration

  • recommended starting dose is 5 mg once daily
  • can be increased at 2-week intervals up to 40 mg
  • more frequent dosing regimen is unlikely to be beneficial

Interaction

  • should be used with care when myocardial depressants or inhibitors of AV conduction are used concurrently
  • not to be combined with other beta-blockers
  • use caution when co-administered with CYP2D6 inhibitors

Contraindications

  • severe bradycardia
  • heart block greater than first degree
  • cardiogenic shock
  • decompensated cardiac failure
  • sick sinus syndrome
  • severe hepatic impairment
  • hypersensitivity to any component of this product

Side Effects

  • headache
  • nausea
  • bradycardia

Precautions & Warnings

  • abrupt cessation of therapy
  • cardiac failure
  • angina and acute myocardial infarction
  • bronchospastic diseases
  • anesthesia and major surgery
  • diabetes and hypoglycemia
  • thyrotoxicosis
  • peripheral vascular disease
  • non-dihydropyridine calcium channel blockers

Use in Special Populations

  • impaired renal function
  • impaired hepatic function
  • risk of anaphylactic reactions

Therapeutic Class

  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

  • Keep below 30°C temperature
  • away from light & moisture
  • Keep out of the reach of children

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