Linatab M ER 2.5 mg+1000 mg (Tablet (Extended Release))

Unit Price: ৳ 16.00 (3 x 6: ৳ 288.00)
Strip Price: ৳ 96.00

Medicine Details

Category Details
Generic Linagliptin metformin hydrochloride
Company Incepta pharmaceuticals ltd
Also available as
Linatab m 25 mg tablet Linatab m 25 mg tablet Linatab m 25 mg tablet Linatab m er 5 mg tablet

Indications

  • Improves glycemic control in adults with type 2 diabetes mellitus
  • Adjunct to diet and exercise

Pharmacology

  • Inhibits DPP-4 enzyme
  • Increases active incretin hormones
  • Stimulates insulin release
  • Decreases glucagon secretion
  • Lowers basal and postprandial plasma glucose
  • Improves insulin sensitivity
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerability
  • Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals
  • Gradual dose escalation to reduce gastrointestinal side effects
  • Different doses for patients currently treated with or without Metformin Hydrochloride
  • Extended-release tablet options

Interaction

  • Interaction with cationic drugs
  • Potential drug interaction with carbonic anhydrase inhibitors
  • Inducers of P-glycoprotein and CYP3A4 enzymes
  • Drugs affecting glycemic control

Contraindications

  • Not for patients with renal impairment
  • Contraindicated in acute or chronic metabolic acidosis
  • Hypersensitivity to Linagliptin or Metformin Hydrochloride

Side Effects

  • Nasopharyngitis
  • Diarrhea
  • Hypoglycemia, especially with sulfonylureas

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Use during pregnancy only if clearly needed
  • Caution during lactation

Precautions & Warnings

  • Discontinue in case of lactic acidosis or suspected pancreatitis
  • Monitor Vitamin B12 levels
  • Symptoms and precautions for lactic acidosis
  • Instructions for alcohol, other medicines, counseling, travel, and emergencies
  • Risk of hypoglycemia

Overdose Effects

  • Usual supportive measures for overdose
  • Metformin Hydrochloride is dialyzable
  • No dose-related adverse drug reactions with Linagliptin
  • Reported hypoglycemia and lactic acidosis in overdose cases

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Store below 30°C
  • Protected from light & moisture
  • Keep out of the reach of children

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