Losucon M 1 mg+500 mg (Tablet (Sustained Release))

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Glimepiride metformin
Company Incepta pharmaceuticals ltd
Also available as
Losucon m 2 mg tablet

Indications

  • Adjunct to diet and exercise in type 2 diabetes mellitus patients
  • Adequate glycemic control
  • Combination therapy of glimepiride and metformin

Pharmacology

  • Sulfonylurea antidiabetic agent
  • Decreases blood glucose concentration
  • Stimulates the release of insulin
  • Improves insulin sensitivity
  • Reduces basal hepatic glucose production
  • Increases peripheral tissue sensitivity to insulin

Dosage

  • Governing by desired blood glucose level
  • Lowest dosage sufficient for metabolic control
  • Regular blood and urine glucose level measurement
  • Maximum recommended dose: 8 mg glimepiride, 2000 mg metformin

Administration

  • Swallowed whole, not crushed or chewed

Interaction

  • Metabolized by cytochrome P450 2C9 (CYP2C9)
  • Potentiation of blood-glucose-lowering effect with concomitant drugs
  • Weakening of blood-glucose-lowering effect with concomitant drugs
  • Alcohol intake may potentiate or weaken action

Contraindications

  • Hypersensitivity to glimepiride, metformin, sulfonylureas, sulfonamides
  • Pregnant and breastfeeding women
  • Severe impairment of liver function
  • Severe renal failure or dysfunction

Side Effects

  • Hypoglycemia
  • Visual impairment
  • Gastrointestinal symptoms
  • Hepatitis and elevation of liver enzyme levels
  • Alopecia
  • Allergic or pseudo allergic reactions

Pregnancy & Lactation

  • Glimepiride must not be taken during pregnancy
  • Metformin should not be used during pregnancy
  • Glimepiride must not be taken by breastfeeding women
  • Metformin excreted into milk, decision should be made whether to discontinue nursing

Precautions & Warnings

  • Increased risk of hypoglycemia in initial weeks of treatment
  • Caution in patients with G6PD-deficiency
  • Regular monitoring of thyroid-stimulating hormone levels

Use in Special Populations

  • Insufficient data for pediatric use
  • Assessment of GFR before initiation of treatment with metformin
  • Renal function assessment in elderly and at increased risk

Overdose Effects

  • Severe life-threatening hypoglycemia
  • Lactic acidosis
  • Pancreatitis may occur in the context of a metformin overdose

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Cool and dry storage
  • Protected from light

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