Origano DR 360 mg (Tablet (Delayed Release))

Indications

• Prophylaxis of organ rejection in kidney transplant in adults
• Prophylaxis of organ rejection in pediatric kidney transplant patients aged 5 and older

Pharmacology

• Mycophenolic acid delayed-release tablets are an enteric coated formulation of mycophenolate sodium
• Immunosuppressive agent
• Inhibitor of inosine monophosphate dehydrogenase (IMPDH)
• Cytostatic effects on lymphocytes
• Prevents acute rejection of kidney and heart allotransplantation
• Decreases antibody production

Dosage & Administration

• Recommended dose for adults: 720 mg twice daily
• Recommended dose for pediatric patients at least 6 months post-transplant: 400 mg/m2 twice daily
• Different dosing for pediatric patients based on body surface area
• Tablets should be taken on an empty stomach, 1 hour before or 2 hours after food intake
• Tablets should not be crushed, chewed, or cut prior to ingesting

Interaction

• Caution with concomitant administration of antacids, azathioprine, cyclosporin, rifampin, sevelamer, cholestyramine, acyclovir, metronidazole, hormonal contraceptives

Contraindications

• Not to be used interchangeably with mycophenolate mofetil tablets and capsules without physician supervision

Side Effects

• Common adverse reactions include anemia, leukopenia, constipation, diarrhea, vomiting, dyspepsia, urinary tract infection, CMV infection, insomnia, postoperative pain

Pregnancy & Lactation

• Pregnancy Category D - can cause fetal harm
• Discontinue Mycophenolic acid during lactation or discontinue nursing within 6 weeks after stopping therapy
• Consider the importance of the drug to the mother

Precautions & Warnings

• Caution due to embryofetal toxicity
• Increased risk of new or reactive viral infections
• Risk of blood dyscrasias including pure red cell aplasia
• Risk of serious GI tract complications
• May increase the risk of developing lymphomas and other malignancies, particularly of the skin
• Avoid use of live vaccine during treatment

Overdose Effects

• No data available

Therapeutic Class

• Immunosuppressant

Storage Conditions

• Store at 25°C
• Keep out of reach of children

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