Pyridox 20 mg+20 mg (Tablet (Extended Release))

Indications

• Treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management

Pharmacology

• Doxylamine Succinate is an antihistamine that blocks Histamine (H1) receptor
• Pyridoxine Hydrochloride is a vitamin B6 analog with antiemetic properties

Dosage & Administration

• Initial dose of one tablet orally at bedtime
• Maximum recommended dose of two tablets per day
• Take on an empty stomach with a glass of water

Interaction

• Contraindicated with monoamine oxidase inhibitors (MAOIs)
• Not recommended with alcohol and other CNS depressants

Contraindications

• Known hypersensitivity to the ingredients
• Contraindicated with monoamine oxidase (MAO) inhibitors

Side Effects

• Somnolence or accidents with CNS depressants

Pregnancy & Lactation

• Pregnancy category A
• Excreted into breast milk, caution needed while breastfeeding

Precautions & Warnings

• May cause somnolence, avoid driving or operating heavy machinery
• Use with caution in women with asthma, increased intraocular pressure, narrow angle glaucoma, etc.

Overdose Effects

• Signs and symptoms of overdose may include restlessness, dryness of mouth, dilated pupils, sleepiness, vertigo, mental confusion, and tachycardia
• At toxic doses, exhibits anticholinergic effects, including seizures, rhabdomyolysis, and acute renal failure

Therapeutic Class

• Anti-emetic drugs

Storage Conditions

• Store at below 30°C in a dry place protected from light
• Keep out of reach of children

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